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• W2531478319 abstract "Egg or sperm? The mechanism of sexual fate decision in germ cells has been a long‐standing issue in biology. A recent analysis identified foxl3 as a gene that determines the sexual fate decision of germ cells in the teleost fish, medaka. foxl3 /Foxl3 acts in female germline stem cells to repress commitment into male fate (spermatogenesis), indicating that the presence of mitotic germ cells in the female is critical for continuous sexual fate decision of germ cells in medaka gonads. Interestingly, foxl3 is found in most vertebrate genomes except for mammals. This provides the interesting possibility that the sexual fate of germ cells in mammals is determined in a different way compared to foxl 3‐possessing vertebrates. Considering the fact that germline stem cells are the cells where foxl3 begins to express and sexual fate decision initiates and mammalian ovary does not have typical germline stem cells, the mechanism in mammals may have been co‐evolved with germline stem cell loss in mammalian ovary." @default.
• W2531478319 created "2016-10-21" @default.
• W2531478319 creator A5074011702 @default.
• W2531478319 date "2016-10-04" @default.
• W2531478319 modified "2023-10-16" @default.
• W2531478319 title "Germline stem cells are critical for sexual fate decision of germ cells" @default.
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• W2531478319 doi "https://doi.org/10.1002/bies.201600045" @default.
• W2531478319 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5132020" @default.
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