FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2531594906> ?p ?o ?g. }

• W2531594906 endingPage "1222" @default.
• W2531594906 startingPage "1222" @default.
• W2531594906 abstract "To investigate the effect of lycopene extracted from tomatoes (LycT) on ultrastructure, glycolytic enzymes, cell proliferation markers and hypoxia during N-Nitrosodiethylamine (NDEA)-induced hepatocarcinogenesis.Female BALB/c mice were randomly divided into four groups: The Control, NDEA (200 mg NDEA/kg b.w. given i.p.), LycT (5 mg/kg b.w. given orally on alternate days) and LycT + NDEA group. The mRNA and protein expression of various cell proliferation markers (PCNA, Cyclin D1, and p21) were assessed by reverse transcription-polymerase chain reaction and enzyme linked immunosorbent assay, respectively. The ultrastructure of hepatic tissue was analyzed using scanning and transmission electron microscopy. The enzymatic activity of glycolytic enzymes was estimated using standardized protocols, while glucose-6-phosphate dehydrogenase activity level was estimated using a kit obtained from Reckon Diagnostic P. Ltd. (India).Uncontrolled proliferation in the liver of NDEA (P ≤ 0.001) mice was evident from the high expression of cell-proliferation associated genes (PCNA, Cyclin D1, and p21) when compared to control and LycT mice. In addition, enhanced activities of hexokinase, phosphoglucoisomerase, aldolase, glucose-6-phosphate dehydrogenase and hypoxia-inducible factor-1α were observed in NDEA mice as compared to control (P ≤ 0.001) and LycT (P ≤ 0.001) mice. The alterations in hepatic ultrastructure observed in the NDEA group correlated with the changes in the above parameters. LycT pre-treatment in NDEA-challenged mice ameliorated the investigated pathways disrupted by NDEA treatment. Moreover, hepatic electron micrographs from the LycT + NDEA group showed increased macrophages, apoptotic bodies and well-differentiated hepatocellular carcinoma (HCC) in comparison to undifferentiated HCC as observed in the NDEA treated group.This study demonstrates that dietary supplementation with LycT has a multidimensional role in preventing HCC development." @default.
• W2531594906 created "2016-10-21" @default.
• W2531594906 creator A5010728274 @default.
• W2531594906 creator A5013875129 @default.
• W2531594906 creator A5077329849 @default.
• W2531594906 creator A5080662688 @default.
• W2531594906 date "2016-01-01" @default.
• W2531594906 modified "2023-09-27" @default.
• W2531594906 title "Lycopene modulates cellular proliferation, glycolysis and hepatic ultrastructure during hepatocellular carcinoma" @default.
• W2531594906 cites W1493099730 @default.
• W2531594906 cites W150216847 @default.
• W2531594906 cites W1564046328 @default.
• W2531594906 cites W1757407923 @default.
• W2531594906 cites W1775749144 @default.
• W2531594906 cites W1925560176 @default.
• W2531594906 cites W1939887442 @default.
• W2531594906 cites W1975812441 @default.
• W2531594906 cites W1983734516 @default.
• W2531594906 cites W1996582543 @default.
• W2531594906 cites W1996592883 @default.
• W2531594906 cites W1999687531 @default.
• W2531594906 cites W2005685522 @default.
• W2531594906 cites W2007727330 @default.
• W2531594906 cites W2011156810 @default.
• W2531594906 cites W2018539520 @default.
• W2531594906 cites W2018547004 @default.
• W2531594906 cites W2021181675 @default.
• W2531594906 cites W2025772032 @default.
• W2531594906 cites W2028897202 @default.
• W2531594906 cites W2029370600 @default.
• W2531594906 cites W2031475147 @default.
• W2531594906 cites W2036109448 @default.
• W2531594906 cites W2036629112 @default.
• W2531594906 cites W2044855387 @default.
• W2531594906 cites W2046100445 @default.
• W2531594906 cites W2048041327 @default.
• W2531594906 cites W2051908102 @default.
• W2531594906 cites W2054483088 @default.
• W2531594906 cites W2058535519 @default.
• W2531594906 cites W2061949605 @default.
• W2531594906 cites W2062878761 @default.
• W2531594906 cites W2065168568 @default.
• W2531594906 cites W2066819763 @default.
• W2531594906 cites W2088544203 @default.
• W2531594906 cites W2109292270 @default.
• W2531594906 cites W2110989494 @default.
• W2531594906 cites W2115400086 @default.
• W2531594906 cites W2115957952 @default.
• W2531594906 cites W2121091862 @default.
• W2531594906 cites W2124451840 @default.
• W2531594906 cites W2151028908 @default.
• W2531594906 cites W2155790078 @default.
• W2531594906 cites W2166362744 @default.
• W2531594906 cites W2174438281 @default.
• W2531594906 cites W2323815567 @default.
• W2531594906 cites W2418765478 @default.
• W2531594906 cites W2485973683 @default.
• W2531594906 cites W4243903519 @default.
• W2531594906 cites W4253184049 @default.
• W2531594906 doi "https://doi.org/10.4254/wjh.v8.i29.1222" @default.
• W2531594906 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5067442" @default.
• W2531594906 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27803767" @default.
• W2531594906 hasPublicationYear "2016" @default.
• W2531594906 type Work @default.
• W2531594906 sameAs 2531594906 @default.
• W2531594906 citedByCount "21" @default.
• W2531594906 countsByYear W25315949062017 @default.
• W2531594906 countsByYear W25315949062018 @default.
• W2531594906 countsByYear W25315949062019 @default.
• W2531594906 countsByYear W25315949062020 @default.
• W2531594906 countsByYear W25315949062021 @default.
• W2531594906 countsByYear W25315949062022 @default.
• W2531594906 countsByYear W25315949062023 @default.
• W2531594906 crossrefType "journal-article" @default.
• W2531594906 hasAuthorship W2531594906A5010728274 @default.
• W2531594906 hasAuthorship W2531594906A5013875129 @default.
• W2531594906 hasAuthorship W2531594906A5077329849 @default.
• W2531594906 hasAuthorship W2531594906A5080662688 @default.
• W2531594906 hasBestOaLocation W25315949061 @default.
• W2531594906 hasConcept C126322002 @default.
• W2531594906 hasConcept C134018914 @default.
• W2531594906 hasConcept C153911025 @default.
• W2531594906 hasConcept C16685009 @default.
• W2531594906 hasConcept C181199279 @default.
• W2531594906 hasConcept C190283241 @default.
• W2531594906 hasConcept C199835354 @default.
• W2531594906 hasConcept C20251656 @default.
• W2531594906 hasConcept C2778019345 @default.
• W2531594906 hasConcept C2779826832 @default.
• W2531594906 hasConcept C29537977 @default.
• W2531594906 hasConcept C34688535 @default.
• W2531594906 hasConcept C502942594 @default.
• W2531594906 hasConcept C55493867 @default.
• W2531594906 hasConcept C62112901 @default.
• W2531594906 hasConcept C71924100 @default.
• W2531594906 hasConcept C86803240 @default.
• W2531594906 hasConceptScore W2531594906C126322002 @default.
• W2531594906 hasConceptScore W2531594906C134018914 @default.

• next