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- W2531609721 abstract "Quelques cas de surdité sous-hydroxychloroquine ont été décrits dans la littérature, la responsabilité de l’hydroxychloroquine restant cependant difficile à établir. Nous rapportons le premier cas, à notre connaissance, de réintroduction positive de l’hydroxychloroquine à l’origine d’une surdité, chez une femme traitée pour un lupus systémique. Une revue des cas de surdité sous-hydroxychloroquine enregistrés dans la base nationale de pharmacovigilance permet de recenser au 31 décembre 2015, 23 observations de surdité lors de traitement par hydroxychloroquine dont 8 fois chez des patients lupiques. Malgré son excellente tolérance et un rapport efficacité–effet indésirable important dans le lupus, cette observation apporte des arguments en faveur d’une ototoxicité possible de l’hydroxychloroquine. Several cases of hearing loss induced by hydroxychloroquine have been reported in the literature but the role of hydroxychloroquine still remains debated. We report the first case, to our knowledge, of hearing loss induced by hydroxychloroquine with a positive re challenge in a woman treated for systemic lupus. An analysis of the French pharmacovigilance database allowed to identify 23 additional cases of hearing loss in patients treated with hydroxychloroquine and, among them, 8 had systemic lupus. Despite an excellent tolerance and high efficacy–side effect ratio, this case report adds some evidence for an otoxicity of hydroxychloroquine." @default.
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- W2531609721 date "2017-05-01" @default.
- W2531609721 modified "2023-10-01" @default.
- W2531609721 title "Surdité sous-hydroxychloroquine : premier cas de réintroduction positive et analyse de la base française de pharmacovigilance" @default.
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- W2531609721 doi "https://doi.org/10.1016/j.revmed.2016.07.008" @default.
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