FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2531623456> ?p ?o ?g. }

• W2531623456 endingPage "4820" @default.
• W2531623456 startingPage "4813" @default.
• W2531623456 abstract "Uveal melanoma is the most common intraocular malignant tumor in adults. Chrysin is a flavonoid present in honey, propolis, various plants and herbs. In the present study, the cytotoxic effects of chrysin were investigated on human uveal melanoma cell lines (M17 and SP6.5) and associated signaling pathways, and a comparison to the effects on normal ocular cells [scleral fibroblasts and retinal pigment epithelial (RPE) cells] was performed. The effects of chrysin on cell viability were assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Cell apoptosis was determined by using terminal deoxynucleotidyl transferase mediated dUTP nick end‑labeling assay. Mitochondrial permeability was determined by JC‑1 fluorescein analysis. Cytosol cytochrome c levels, and the activities of caspase-3, ‑8 and ‑9 were measured by enzyme‑linked immunosorbent assay or colorimetric assay. Chrysin reduced the viability of cultured human melanoma cells in a dose‑dependent manner (0, 10, 30 and 100 µM) with IC50 at 28.3 and 35.8 µM in SP6.5 and M17 cell lines, respectively. Chrysin at 30‑100 µM levels selectively reduced the viability of melanoma cells without affecting the viability of scleral fibroblasts and RPE cells. Chrysin increased mitochondrial permeability, the levels of cytosol cytochrome c, and caspase‑9 and ‑3 activities, but not capase‑8 activity in uveal melanoma cells. The results of the present study indicate that chrysin induces apoptosis of human uveal melanoma cells via the mitochondrial signaling pathway and suggest that chrysin may be a promising agent in the treatment of uveal melanoma." @default.
• W2531623456 created "2016-10-21" @default.
• W2531623456 creator A5022034616 @default.
• W2531623456 creator A5041294700 @default.
• W2531623456 creator A5052214110 @default.
• W2531623456 creator A5059447916 @default.
• W2531623456 creator A5063902689 @default.
• W2531623456 creator A5077469510 @default.
• W2531623456 date "2016-10-13" @default.
• W2531623456 modified "2023-10-15" @default.
• W2531623456 title "Chrysin induces cell apoptosis in human uveal melanoma cells via intrinsic apoptosis" @default.
• W2531623456 cites W1552243592 @default.
• W2531623456 cites W176877720 @default.
• W2531623456 cites W1970014118 @default.
• W2531623456 cites W1971050728 @default.
• W2531623456 cites W1972972601 @default.
• W2531623456 cites W1974211218 @default.
• W2531623456 cites W1976586638 @default.
• W2531623456 cites W1976587524 @default.
• W2531623456 cites W2000350902 @default.
• W2531623456 cites W2006431138 @default.
• W2531623456 cites W2015705067 @default.
• W2531623456 cites W2018032989 @default.
• W2531623456 cites W2018755820 @default.
• W2531623456 cites W2019660215 @default.
• W2531623456 cites W2020316909 @default.
• W2531623456 cites W2024865643 @default.
• W2531623456 cites W2025436220 @default.
• W2531623456 cites W2026130443 @default.
• W2531623456 cites W2028989607 @default.
• W2531623456 cites W2044499234 @default.
• W2531623456 cites W2052337863 @default.
• W2531623456 cites W2053248742 @default.
• W2531623456 cites W2055835855 @default.
• W2531623456 cites W2061857205 @default.
• W2531623456 cites W2087326187 @default.
• W2531623456 cites W2115379667 @default.
• W2531623456 cites W2134855813 @default.
• W2531623456 cites W2136506025 @default.
• W2531623456 cites W2141087913 @default.
• W2531623456 cites W2141237503 @default.
• W2531623456 cites W2141586747 @default.
• W2531623456 cites W2146984617 @default.
• W2531623456 cites W2147357406 @default.
• W2531623456 cites W2150497176 @default.
• W2531623456 cites W2154758903 @default.
• W2531623456 cites W2165248579 @default.
• W2531623456 cites W4243642137 @default.
• W2531623456 cites W70061047 @default.
• W2531623456 doi "https://doi.org/10.3892/ol.2016.5251" @default.
• W2531623456 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5228444" @default.
• W2531623456 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28105189" @default.
• W2531623456 hasPublicationYear "2016" @default.
• W2531623456 type Work @default.
• W2531623456 sameAs 2531623456 @default.
• W2531623456 citedByCount "28" @default.
• W2531623456 countsByYear W25316234562017 @default.
• W2531623456 countsByYear W25316234562018 @default.
• W2531623456 countsByYear W25316234562019 @default.
• W2531623456 countsByYear W25316234562020 @default.
• W2531623456 countsByYear W25316234562021 @default.
• W2531623456 countsByYear W25316234562022 @default.
• W2531623456 countsByYear W25316234562023 @default.
• W2531623456 crossrefType "journal-article" @default.
• W2531623456 hasAuthorship W2531623456A5022034616 @default.
• W2531623456 hasAuthorship W2531623456A5041294700 @default.
• W2531623456 hasAuthorship W2531623456A5052214110 @default.
• W2531623456 hasAuthorship W2531623456A5059447916 @default.
• W2531623456 hasAuthorship W2531623456A5063902689 @default.
• W2531623456 hasAuthorship W2531623456A5077469510 @default.
• W2531623456 hasBestOaLocation W25316234561 @default.
• W2531623456 hasConcept C153911025 @default.
• W2531623456 hasConcept C185592680 @default.
• W2531623456 hasConcept C190283241 @default.
• W2531623456 hasConcept C2777658100 @default.
• W2531623456 hasConcept C2778004101 @default.
• W2531623456 hasConcept C2779054382 @default.
• W2531623456 hasConcept C2779478871 @default.
• W2531623456 hasConcept C29311851 @default.
• W2531623456 hasConcept C502942594 @default.
• W2531623456 hasConcept C53227056 @default.
• W2531623456 hasConcept C55493867 @default.
• W2531623456 hasConcept C86803240 @default.
• W2531623456 hasConceptScore W2531623456C153911025 @default.
• W2531623456 hasConceptScore W2531623456C185592680 @default.
• W2531623456 hasConceptScore W2531623456C190283241 @default.
• W2531623456 hasConceptScore W2531623456C2777658100 @default.
• W2531623456 hasConceptScore W2531623456C2778004101 @default.
• W2531623456 hasConceptScore W2531623456C2779054382 @default.
• W2531623456 hasConceptScore W2531623456C2779478871 @default.
• W2531623456 hasConceptScore W2531623456C29311851 @default.
• W2531623456 hasConceptScore W2531623456C502942594 @default.
• W2531623456 hasConceptScore W2531623456C53227056 @default.
• W2531623456 hasConceptScore W2531623456C55493867 @default.
• W2531623456 hasConceptScore W2531623456C86803240 @default.
• W2531623456 hasIssue "6" @default.
• W2531623456 hasLocation W25316234561 @default.
• W2531623456 hasLocation W25316234562 @default.

• next