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- W2531651639 endingPage "e000088" @default.
- W2531651639 startingPage "e000088" @default.
- W2531651639 abstract "Epidermal growth factor receptor (EGFR) plays a key role in tumour evolution, proliferation and immune evasion, and is one of the most important targets for biological therapy, especially for non-small-cell lung cancer (NSCLC) and colorectal cancer (CRC). In the past 15 years, several EGFR antagonists have been approved for the treatment of NSCLC and metastatic CRC (mCRC). To optimise the use of anti-EGFR agents in clinical practice, various clinical and molecular biomarkers have been investigated, thus moving their indication from unselected to selected populations. Nowadays, anti-EGFR drugs represent a gold-standard therapy for metastatic NSCLC harbouring EGFR activating mutation and for RAS wild-type mCRC. Their clinical efficacy is limited by the presence of intrinsic resistance or the onset of acquired resistance. In this review, we provide an overview of the antitumour activity of EGFR inhibitors in NSCLC and CRC and of mechanisms of resistance, focusing on the development of a personalised approach through 15 years of preclinical and clinical research." @default.
- W2531651639 created "2016-10-21" @default.
- W2531651639 creator A5004016643 @default.
- W2531651639 creator A5006208754 @default.
- W2531651639 creator A5012201620 @default.
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- W2531651639 creator A5032164411 @default.
- W2531651639 creator A5056034569 @default.
- W2531651639 creator A5076690603 @default.
- W2531651639 date "2016-01-01" @default.
- W2531651639 modified "2023-10-14" @default.
- W2531651639 title "Therapeutic value of EGFR inhibition in CRC and NSCLC: 15 years of clinical evidence" @default.
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