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- W2531664025 abstract "Vancomycin has long been considered a drug of last resort. Its efficiency in treating multiple drug-resistant bacterial infections, particularly methicillin-resistant Staphylococcus aureus (MRSA), has had a profound effect on the treatment of life-threatening infections. However, the emergence of resistance to vancomycin is a cause for significant worldwide concern, prompting the urgent development of new effective treatments for antibiotic resistant bacterial infections. Harnessing the benefits of multivalency and cooperativity against vancomycin-resistant strains, we report a Click Chemistry approach towards reengineered vancomycin derivatives and the synthesis of a number of dimers with increased potency against MRSA and vancomycin resistant Enterococci (VRE; VanB). These semi-synthetic dimeric ligands were linked together with great efficiency using the powerful CuAAC reaction, demonstrating high levels of selectivity and purity." @default.
- W2531664025 created "2016-10-21" @default.
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- W2531664025 creator A5076415694 @default.
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- W2531664025 date "2016-11-11" @default.
- W2531664025 modified "2023-09-25" @default.
- W2531664025 title "Reengineering Antibiotics to Combat Bacterial Resistance: Click Chemistry [1,2,3]-Triazole Vancomycin Dimers with Potent Activity against MRSA and VRE" @default.
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- W2531664025 cites W1975488587 @default.
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- W2531664025 doi "https://doi.org/10.1002/chem.201604765" @default.
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