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- W2531709435 endingPage "50" @default.
- W2531709435 startingPage "11" @default.
- W2531709435 abstract "Mitochondria are vital metabolic centers in the cell, containing key enzymes for numerous metabolic pathways, such as the Krebs cycle, urea cycle, iron metabolism, fatty acid oxidation, and heme synthesis, to name a few. Mitochondria are the major site of oxygen consumption for use in oxidative phosphorylation to produce ATP, with reactive oxygen species (ROS) being produced as a by-product of oxygen metabolism. ROS can have deleterious effects on multiple mitochondria-centered activities, leading to the development of numerous diseases, including cancer. Manganese superoxide dismutase (MnSOD) is an essential antioxidant enzyme localized in mitochondria. MnSOD protects the cell from the harmful effects of ROS, in general, and guards against mitochondrial dysfunction, in particular. MnSOD plays a dual role in cancer development, acting as a tumor suppressor during early stages of carcinogenesis and facilitating cancer progression at later stages of development. A greater understanding of the role of MnSOD in preserving mitochondrial function can give important insights for the development of novel therapeutic strategies for the treatment of cancer and other diseases resulting from mitochondrial dysfunction." @default.
- W2531709435 created "2016-10-21" @default.
- W2531709435 creator A5005401059 @default.
- W2531709435 creator A5068073955 @default.
- W2531709435 date "2016-01-01" @default.
- W2531709435 modified "2023-09-27" @default.
- W2531709435 title "Manganese Superoxide Dismutase (MnSOD) and Its Importance in Mitochondrial Function and Cancer" @default.
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