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- W253173868 abstract "Tourette syndrome (TS) is a neurodevelopmental syndrome characterized by motor and vocal tics, as well as by sensory abnormalities; it is frequently comorbid with other neuropsychiatric conditions such as obsessive-compulsive disorder (OCD). The construction of valid animal models of such conditions presents particular challenges. All three normal domains in which validity is assessed are problematic: face validity because the symptomatology is complex and difficult to define in an animal; predictive validity because available pharmacological interventions are of limited efficacy and specificity; and construct validity because our understanding of the pathophysiology of these complex disorders remains rudimentary. Despite these challenges, a variety of animal models of these conditions have been described. Models of TS have focused on dysregulation of dopamine and of inhibitory transmission within the cortico-basal ganglia circuitry. Models of OCD have focused on the same circuitry, as well as on serotonergic modulation and on a variety of behavioral manipulations. No established models have yet been convincingly shown to fully recapitulate the pathophysiology of these prevalent diseases; but several have cast important insight on underlying neurobiological processes and are likely to continue to be informative going forward." @default.
- W253173868 created "2016-06-24" @default.
- W253173868 creator A5001094886 @default.
- W253173868 date "2015-01-01" @default.
- W253173868 modified "2023-09-27" @default.
- W253173868 title "Animal Models of Tourette Syndrome and Obsessive-Compulsive Disorder" @default.
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