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• W2531750597 endingPage "2025" @default.
• W2531750597 startingPage "2025" @default.
• W2531750597 abstract "<h3>Importance</h3> More than 100 million units of blood are collected worldwide each year, yet the indication for red blood cell (RBC) transfusion and the optimal length of RBC storage prior to transfusion are uncertain. <h3>Objective</h3> To provide recommendations for the target hemoglobin level for RBC transfusion among hospitalized adult patients who are hemodynamically stable and the length of time RBCs should be stored prior to transfusion. <h3>Evidence Review</h3> Reference librarians conducted a literature search for randomized clinical trials (RCTs) evaluating hemoglobin thresholds for RBC transfusion (1950-May 2016) and RBC storage duration (1948-May 2016) without language restrictions. The results were summarized using the Grading of Recommendations Assessment, Development and Evaluation method. For RBC transfusion thresholds, 31 RCTs included 12 587 participants and compared restrictive thresholds (transfusion not indicated until the hemoglobin level is 7-8 g/dL) with liberal thresholds (transfusion not indicated until the hemoglobin level is 9-10 g/dL). The summary estimates across trials demonstrated that restrictive RBC transfusion thresholds were not associated with higher rates of adverse clinical outcomes, including 30-day mortality, myocardial infarction, cerebrovascular accident, rebleeding, pneumonia, or thromboembolism. For RBC storage duration, 13 RCTs included 5515 participants randomly allocated to receive fresher blood or standard-issue blood. These RCTs demonstrated that fresher blood did not improve clinical outcomes. <h3>Findings</h3> It is good practice to consider the hemoglobin level, the overall clinical context, patient preferences, and alternative therapies when making transfusion decisions regarding an individual patient. Recommendation 1: a restrictive RBC transfusion threshold in which the transfusion is not indicated until the hemoglobin level is 7 g/dL is recommended for hospitalized adult patients who are hemodynamically stable, including critically ill patients, rather than when the hemoglobin level is 10 g/dL (strong recommendation, moderate quality evidence). A restrictive RBC transfusion threshold of 8 g/dL is recommended for patients undergoing orthopedic surgery, cardiac surgery, and those with preexisting cardiovascular disease (strong recommendation, moderate quality evidence). The restrictive transfusion threshold of 7 g/dL is likely comparable with 8 g/dL, but RCT evidence is not available for all patient categories. These recommendations do not apply to patients with acute coronary syndrome, severe thrombocytopenia (patients treated for hematological or oncological reasons who are at risk of bleeding), and chronic transfusion–dependent anemia (not recommended due to insufficient evidence). Recommendation 2: patients, including neonates, should receive RBC units selected at any point within their licensed dating period (standard issue) rather than limiting patients to transfusion of only fresh (storage length: <10 days) RBC units (strong recommendation, moderate quality evidence). <h3>Conclusions and Relevance</h3> Research in RBC transfusion medicine has significantly advanced the science in recent years and provides high-quality evidence to inform guidelines. A restrictive transfusion threshold is safe in most clinical settings and the current blood banking practices of using standard-issue blood should be continued." @default.
• W2531750597 created "2016-10-21" @default.
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• W2531750597 date "2016-11-15" @default.
• W2531750597 modified "2023-10-16" @default.
• W2531750597 title "Clinical Practice Guidelines From the AABB" @default.
• W2531750597 cites W115624719 @default.
• W2531750597 cites W1247968195 @default.
• W2531750597 cites W127034668 @default.
• W2531750597 cites W1483788291 @default.
• W2531750597 cites W1528208954 @default.
• W2531750597 cites W1534370505 @default.
• W2531750597 cites W1568317078 @default.
• W2531750597 cites W1608039513 @default.
• W2531750597 cites W1632666839 @default.
• W2531750597 cites W166452611 @default.
• W2531750597 cites W170502642 @default.
• W2531750597 cites W1768469743 @default.
• W2531750597 cites W1806016548 @default.
• W2531750597 cites W1813468147 @default.
• W2531750597 cites W1825416676 @default.
• W2531750597 cites W1847386200 @default.
• W2531750597 cites W1926136353 @default.
• W2531750597 cites W1951303271 @default.
• W2531750597 cites W1968110103 @default.
• W2531750597 cites W1980472079 @default.
• W2531750597 cites W1982577232 @default.
• W2531750597 cites W1993563216 @default.
• W2531750597 cites W1996494215 @default.
• W2531750597 cites W1998564207 @default.
• W2531750597 cites W2007137403 @default.
• W2531750597 cites W2011112804 @default.
• W2531750597 cites W2012240163 @default.
• W2531750597 cites W2016561232 @default.
• W2531750597 cites W2023556803 @default.
• W2531750597 cites W2027561524 @default.
• W2531750597 cites W2028790836 @default.
• W2531750597 cites W2030466615 @default.
• W2531750597 cites W2031032188 @default.
• W2531750597 cites W2035934312 @default.
• W2531750597 cites W2038729642 @default.
• W2531750597 cites W2043293685 @default.
• W2531750597 cites W2044929497 @default.
• W2531750597 cites W2049036705 @default.
• W2531750597 cites W2051158364 @default.
• W2531750597 cites W2055767544 @default.
• W2531750597 cites W2059013002 @default.
• W2531750597 cites W2060607069 @default.
• W2531750597 cites W2061632494 @default.
• W2531750597 cites W2067800932 @default.
• W2531750597 cites W2068785908 @default.
• W2531750597 cites W2070520385 @default.
• W2531750597 cites W2072224369 @default.
• W2531750597 cites W2075064256 @default.
• W2531750597 cites W2077710671 @default.
• W2531750597 cites W2081670726 @default.
• W2531750597 cites W2081719666 @default.
• W2531750597 cites W2093059783 @default.
• W2531750597 cites W2094815596 @default.
• W2531750597 cites W2095095757 @default.
• W2531750597 cites W2100630414 @default.
• W2531750597 cites W2101005384 @default.
• W2531750597 cites W2105397247 @default.
• W2531750597 cites W2106407512 @default.
• W2531750597 cites W2107328434 @default.
• W2531750597 cites W2107921622 @default.
• W2531750597 cites W2110292826 @default.
• W2531750597 cites W2115783704 @default.
• W2531750597 cites W2116957157 @default.
• W2531750597 cites W2119179413 @default.
• W2531750597 cites W2125178621 @default.
• W2531750597 cites W2126605676 @default.
• W2531750597 cites W2126770702 @default.
• W2531750597 cites W2126853459 @default.
• W2531750597 cites W2127110326 @default.
• W2531750597 cites W21341163 @default.
• W2531750597 cites W2136098489 @default.
• W2531750597 cites W2136535020 @default.
• W2531750597 cites W2141224996 @default.
• W2531750597 cites W2147368252 @default.
• W2531750597 cites W2151125432 @default.
• W2531750597 cites W2155495795 @default.
• W2531750597 cites W2156870897 @default.

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