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• W2531782817 abstract "A copper-mediated nucleophilic radiofluorination of aryl- and vinylstannanes with [18F]KF is described. This method is fast, uses commercially available reagents, and is compatible with both electron-rich and electron-deficient arene substrates. This method has been applied to the manual synthesis of a variety of clinically relevant radiotracers including protected [18F]F-phenylalanine and [18F]F-DOPA. In addition, an automated synthesis of [18F]MPPF is demonstrated that delivers a clinically validated dose of 200 ± 20 mCi with a high specific activity of 2400 ± 900 Ci/mmol." @default.
• W2531782817 created "2016-10-21" @default.
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• W2531782817 date "2016-10-10" @default.
• W2531782817 modified "2023-10-14" @default.
• W2531782817 title "Copper-Mediated Radiofluorination of Arylstannanes with [¹⁸F]KF" @default.
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• W2531782817 doi "https://doi.org/10.1021/acs.orglett.6b02911" @default.
• W2531782817 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5078836" @default.
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