FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2531784941> ?p ?o ?g. }

• W2531784941 endingPage "4426" @default.
• W2531784941 startingPage "4419" @default.
• W2531784941 abstract "MicroRNA‑221 and microRNA‑222 (miR‑221/222) have been identified as oncogenes and confirmed to be overexpressed in various types of cancer. However, the regulation mechanism of miR‑221/222 in oral squamous cell carcinoma (OSCC) remains to be fully elucidated. Previously, an miR‑221/222 sponge was successfully constructed and its effect on the downregulation of miR‑221/222 expression was investigated. In the present study, the dual luciferase reporter assay revealed a phosphatase and tensin homolog (PTEN) deletion on chromosome 10 to be a target gene of miR‑221/222. It was also demonstrated that miR‑221/222 suppression by transfection with an miR‑221/222 sponge in vitro resulted in upregulation of PTEN. Notably, the proliferation and invasiveness of the miR‑221/222 sponge‑transfected cells was significantly inhibited, while apoptosis was promoted, when determined by Cell Counting Kit‑8, Transwell assays and flow cytometry. The results of the present study prove that miR‑221/222 may downregulate the expression of PTEN in OSCC cells and function as oncogenes, providing a novel insight into the underlying mechanism of OSCC tumorigenesis. The present study suggests that upregulating the expression of PTEN by downregulation of miR‑221/222 may be a potential treatment for OSCC." @default.
• W2531784941 created "2016-10-21" @default.
• W2531784941 creator A5007707979 @default.
• W2531784941 creator A5016945454 @default.
• W2531784941 creator A5068289835 @default.
• W2531784941 creator A5068726463 @default.
• W2531784941 creator A5069277702 @default.
• W2531784941 creator A5079017616 @default.
• W2531784941 creator A5091468414 @default.
• W2531784941 date "2016-10-13" @default.
• W2531784941 modified "2023-09-24" @default.
• W2531784941 title "Downregulation of miR-221/222 by a microRNA sponge promotes apoptosis in oral squamous cell carcinoma cells through upregulation of PTEN" @default.
• W2531784941 cites W137431429 @default.
• W2531784941 cites W1523462018 @default.
• W2531784941 cites W1530269273 @default.
• W2531784941 cites W1540008871 @default.
• W2531784941 cites W1582495617 @default.
• W2531784941 cites W1812191961 @default.
• W2531784941 cites W1972989638 @default.
• W2531784941 cites W1987843795 @default.
• W2531784941 cites W2007214287 @default.
• W2531784941 cites W2007594572 @default.
• W2531784941 cites W2008656707 @default.
• W2531784941 cites W2012071567 @default.
• W2531784941 cites W2021936364 @default.
• W2531784941 cites W2032565321 @default.
• W2531784941 cites W2044601473 @default.
• W2531784941 cites W2056950988 @default.
• W2531784941 cites W2062290101 @default.
• W2531784941 cites W2062615266 @default.
• W2531784941 cites W2074478736 @default.
• W2531784941 cites W2084400739 @default.
• W2531784941 cites W2096334610 @default.
• W2531784941 cites W2099691090 @default.
• W2531784941 cites W2107277218 @default.
• W2531784941 cites W2116929318 @default.
• W2531784941 cites W2134954990 @default.
• W2531784941 cites W2137575089 @default.
• W2531784941 cites W2144066241 @default.
• W2531784941 cites W2144621400 @default.
• W2531784941 cites W2154570280 @default.
• W2531784941 cites W2160754564 @default.
• W2531784941 cites W2160919000 @default.
• W2531784941 cites W2161693225 @default.
• W2531784941 cites W2162674813 @default.
• W2531784941 cites W2176365353 @default.
• W2531784941 cites W2192080449 @default.
• W2531784941 cites W342719612 @default.
• W2531784941 doi "https://doi.org/10.3892/ol.2016.5250" @default.
• W2531784941 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5228168" @default.
• W2531784941 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28101204" @default.
• W2531784941 hasPublicationYear "2016" @default.
• W2531784941 type Work @default.
• W2531784941 sameAs 2531784941 @default.
• W2531784941 citedByCount "37" @default.
• W2531784941 countsByYear W25317849412017 @default.
• W2531784941 countsByYear W25317849412018 @default.
• W2531784941 countsByYear W25317849412019 @default.
• W2531784941 countsByYear W25317849412020 @default.
• W2531784941 countsByYear W25317849412021 @default.
• W2531784941 countsByYear W25317849412022 @default.
• W2531784941 countsByYear W25317849412023 @default.
• W2531784941 crossrefType "journal-article" @default.
• W2531784941 hasAuthorship W2531784941A5007707979 @default.
• W2531784941 hasAuthorship W2531784941A5016945454 @default.
• W2531784941 hasAuthorship W2531784941A5068289835 @default.
• W2531784941 hasAuthorship W2531784941A5068726463 @default.
• W2531784941 hasAuthorship W2531784941A5069277702 @default.
• W2531784941 hasAuthorship W2531784941A5079017616 @default.
• W2531784941 hasAuthorship W2531784941A5091468414 @default.
• W2531784941 hasBestOaLocation W25317849411 @default.
• W2531784941 hasConcept C104317684 @default.
• W2531784941 hasConcept C121608353 @default.
• W2531784941 hasConcept C127561419 @default.
• W2531784941 hasConcept C145059251 @default.
• W2531784941 hasConcept C1491633281 @default.
• W2531784941 hasConcept C153911025 @default.
• W2531784941 hasConcept C190283241 @default.
• W2531784941 hasConcept C2777609662 @default.
• W2531784941 hasConcept C2779549131 @default.
• W2531784941 hasConcept C2781018059 @default.
• W2531784941 hasConcept C29537977 @default.
• W2531784941 hasConcept C502942594 @default.
• W2531784941 hasConcept C54009773 @default.
• W2531784941 hasConcept C54355233 @default.
• W2531784941 hasConcept C553184892 @default.
• W2531784941 hasConcept C555283112 @default.
• W2531784941 hasConcept C81885089 @default.
• W2531784941 hasConcept C86554907 @default.
• W2531784941 hasConcept C86803240 @default.
• W2531784941 hasConceptScore W2531784941C104317684 @default.
• W2531784941 hasConceptScore W2531784941C121608353 @default.
• W2531784941 hasConceptScore W2531784941C127561419 @default.
• W2531784941 hasConceptScore W2531784941C145059251 @default.
• W2531784941 hasConceptScore W2531784941C1491633281 @default.
• W2531784941 hasConceptScore W2531784941C153911025 @default.
• W2531784941 hasConceptScore W2531784941C190283241 @default.
• W2531784941 hasConceptScore W2531784941C2777609662 @default.

• next