FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2531792064> ?p ?o ?g. }

• W2531792064 endingPage "3944" @default.
• W2531792064 startingPage "3934" @default.
• W2531792064 abstract "Tumor cells can acquire multidrug resistance (MDR) as a result of drug efflux mediated by P-glycoprotein (P-gp). Here we report a targeted delivery system to carry pirarubicin (THP) to MDR breast cancer both in vitro and in vivo. PEG-derivatized vitamin E (PAMV6) amphiphiles loaded with THP were self-assembled in a single step. The PAMV6 micelles showed unimodal size distribution and high drug loading efficiency. Cytotoxicity of PAMV6/THP was higher than that of free THP on MCF-7/ADR cells but comparable to that of THP on MCF-7 cells. PAMV6/THP was able to reverse MDR more than free THP in MCF-7/ADR cells, likely reflecting the remarkably higher intracellular THP concentration in micelle-treated cells and PAMV6-mediated inhibition of P-gp activity. PAMV6/THP micelles were internalized into MCF-7/ADR cells via macropinocytosis and caveolin-mediated endocytosis, further avoiding P-gp-mediated efflux. Mechanistic studies revealed that blank PAMV6 micelles inhibited P-gp activity but did not affect P-gp expression, by significantly reducing mitochondrial membrane potential and slightly decreasing intracellular ATP levels. In a nude mouse xenograft model, PAMV6/THP led to much greater THP accumulation in tumors and much slower tumor growth than free THP. At the same time, PAMV6/THP was associated with significantly less severe bone marrow suppression and organ toxicity than free THP. Our results indicate that this PAMV6-based micelle system holds promise for combating MDR in cancer therapy." @default.
• W2531792064 created "2016-10-21" @default.
• W2531792064 creator A5001421484 @default.
• W2531792064 creator A5014068004 @default.
• W2531792064 creator A5018715980 @default.
• W2531792064 creator A5036939586 @default.
• W2531792064 creator A5041192749 @default.
• W2531792064 creator A5042592599 @default.
• W2531792064 creator A5042772858 @default.
• W2531792064 creator A5044120570 @default.
• W2531792064 creator A5059451847 @default.
• W2531792064 creator A5068210092 @default.
• W2531792064 creator A5070888688 @default.
• W2531792064 creator A5088174174 @default.
• W2531792064 date "2016-10-21" @default.
• W2531792064 modified "2023-10-10" @default.
• W2531792064 title "One-Step Self-Assembling Nanomicelles for Pirarubicin Delivery To Overcome Multidrug Resistance in Breast Cancer" @default.
• W2531792064 cites W109370729 @default.
• W2531792064 cites W1979047809 @default.
• W2531792064 cites W1979108017 @default.
• W2531792064 cites W1985498995 @default.
• W2531792064 cites W1995690527 @default.
• W2531792064 cites W2003110090 @default.
• W2531792064 cites W2007807680 @default.
• W2531792064 cites W2013224924 @default.
• W2531792064 cites W2028531434 @default.
• W2531792064 cites W2029071448 @default.
• W2531792064 cites W2029364244 @default.
• W2531792064 cites W2051332449 @default.
• W2531792064 cites W2060265857 @default.
• W2531792064 cites W2061023797 @default.
• W2531792064 cites W2061215349 @default.
• W2531792064 cites W2069360982 @default.
• W2531792064 cites W2074049796 @default.
• W2531792064 cites W2093231351 @default.
• W2531792064 cites W2097431496 @default.
• W2531792064 cites W2108366087 @default.
• W2531792064 cites W2118234018 @default.
• W2531792064 cites W2122620964 @default.
• W2531792064 cites W2126942012 @default.
• W2531792064 cites W2131313990 @default.
• W2531792064 cites W2142897044 @default.
• W2531792064 cites W2145362882 @default.
• W2531792064 cites W2148287035 @default.
• W2531792064 cites W2152504641 @default.
• W2531792064 cites W2233083012 @default.
• W2531792064 cites W224280792 @default.
• W2531792064 cites W2328605846 @default.
• W2531792064 cites W2331376784 @default.
• W2531792064 cites W2401364052 @default.
• W2531792064 cites W2409971582 @default.
• W2531792064 cites W2439901148 @default.
• W2531792064 cites W2468497753 @default.
• W2531792064 cites W328253405 @default.
• W2531792064 cites W66407225 @default.
• W2531792064 doi "https://doi.org/10.1021/acs.molpharmaceut.6b00712" @default.
• W2531792064 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27744704" @default.
• W2531792064 hasPublicationYear "2016" @default.
• W2531792064 type Work @default.
• W2531792064 sameAs 2531792064 @default.
• W2531792064 citedByCount "14" @default.
• W2531792064 countsByYear W25317920642017 @default.
• W2531792064 countsByYear W25317920642018 @default.
• W2531792064 countsByYear W25317920642019 @default.
• W2531792064 countsByYear W25317920642020 @default.
• W2531792064 countsByYear W25317920642021 @default.
• W2531792064 countsByYear W25317920642022 @default.
• W2531792064 countsByYear W25317920642023 @default.
• W2531792064 crossrefType "journal-article" @default.
• W2531792064 hasAuthorship W2531792064A5001421484 @default.
• W2531792064 hasAuthorship W2531792064A5014068004 @default.
• W2531792064 hasAuthorship W2531792064A5018715980 @default.
• W2531792064 hasAuthorship W2531792064A5036939586 @default.
• W2531792064 hasAuthorship W2531792064A5041192749 @default.
• W2531792064 hasAuthorship W2531792064A5042592599 @default.
• W2531792064 hasAuthorship W2531792064A5042772858 @default.
• W2531792064 hasAuthorship W2531792064A5044120570 @default.
• W2531792064 hasAuthorship W2531792064A5059451847 @default.
• W2531792064 hasAuthorship W2531792064A5068210092 @default.
• W2531792064 hasAuthorship W2531792064A5070888688 @default.
• W2531792064 hasAuthorship W2531792064A5088174174 @default.
• W2531792064 hasConcept C109316439 @default.
• W2531792064 hasConcept C11268172 @default.
• W2531792064 hasConcept C121608353 @default.
• W2531792064 hasConcept C126322002 @default.
• W2531792064 hasConcept C133936738 @default.
• W2531792064 hasConcept C147789679 @default.
• W2531792064 hasConcept C1491633281 @default.
• W2531792064 hasConcept C150903083 @default.
• W2531792064 hasConcept C184651966 @default.
• W2531792064 hasConcept C185592680 @default.
• W2531792064 hasConcept C200082930 @default.
• W2531792064 hasConcept C202751555 @default.
• W2531792064 hasConcept C204258353 @default.
• W2531792064 hasConcept C207001950 @default.
• W2531792064 hasConcept C2776085618 @default.
• W2531792064 hasConcept C2776694085 @default.
• W2531792064 hasConcept C2778707650 @default.

• next