FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2531796630> ?p ?o ?g. }

• W2531796630 abstract "DNA double-strand breaks (DSBs) leading to loss of nucleotides in the transcribed region can be lethal. Classical non-homologous end-joining (C-NHEJ) is the dominant pathway for DSB repair (DSBR) in adult mammalian cells. Here we report that during such DSBR, mammalian C-NHEJ proteins form a multiprotein complex with RNA polymerase II and preferentially associate with the transcribed genes after DSB induction. Depletion of C-NHEJ factors significantly abrogates DSBR in transcribed but not in non-transcribed genes. We hypothesized that nascent RNA can serve as a template for restoring the missing sequences, thus allowing error-free DSBR. We indeed found pre-mRNA in the C-NHEJ complex. Finally, when a DSB-containing plasmid with several nucleotides deleted within the E. coli lacZ gene was allowed time to repair in lacZ-expressing mammalian cells, a functional lacZ plasmid could be recovered from control but not C-NHEJ factor-depleted cells, providing important mechanistic insights into C-NHEJ-mediated error-free DSBR of the transcribed genome." @default.
• W2531796630 created "2016-10-21" @default.
• W2531796630 creator A5030568919 @default.
• W2531796630 creator A5040794773 @default.
• W2531796630 creator A5056507943 @default.
• W2531796630 creator A5061702912 @default.
• W2531796630 creator A5066447821 @default.
• W2531796630 creator A5075844121 @default.
• W2531796630 creator A5079006596 @default.
• W2531796630 creator A5082085789 @default.
• W2531796630 creator A5090703875 @default.
• W2531796630 date "2016-10-05" @default.
• W2531796630 modified "2023-10-17" @default.
• W2531796630 title "Classical non-homologous end-joining pathway utilizes nascent RNA for error-free double-strand break repair of transcribed genes" @default.
• W2531796630 cites W1545448616 @default.
• W2531796630 cites W1976987484 @default.
• W2531796630 cites W1977572530 @default.
• W2531796630 cites W1979442620 @default.
• W2531796630 cites W1981836425 @default.
• W2531796630 cites W1982307936 @default.
• W2531796630 cites W1986320226 @default.
• W2531796630 cites W1988353584 @default.
• W2531796630 cites W1993243592 @default.
• W2531796630 cites W1993350141 @default.
• W2531796630 cites W1997789055 @default.
• W2531796630 cites W2008306394 @default.
• W2531796630 cites W2012040132 @default.
• W2531796630 cites W2016999017 @default.
• W2531796630 cites W2022875583 @default.
• W2531796630 cites W2027765580 @default.
• W2531796630 cites W2033983784 @default.
• W2531796630 cites W2038138598 @default.
• W2531796630 cites W2043682043 @default.
• W2531796630 cites W2049757552 @default.
• W2531796630 cites W2063052190 @default.
• W2531796630 cites W2067458235 @default.
• W2531796630 cites W2074726130 @default.
• W2531796630 cites W2074779681 @default.
• W2531796630 cites W2079197003 @default.
• W2531796630 cites W2083412264 @default.
• W2531796630 cites W2086398516 @default.
• W2531796630 cites W2092128195 @default.
• W2531796630 cites W2093950640 @default.
• W2531796630 cites W2095687796 @default.
• W2531796630 cites W2097027640 @default.
• W2531796630 cites W2097952880 @default.
• W2531796630 cites W2107984184 @default.
• W2531796630 cites W2109879947 @default.
• W2531796630 cites W2111791871 @default.
• W2531796630 cites W2114404734 @default.
• W2531796630 cites W2123241821 @default.
• W2531796630 cites W2144512576 @default.
• W2531796630 cites W2155952235 @default.
• W2531796630 cites W2159812536 @default.
• W2531796630 cites W2164995160 @default.
• W2531796630 cites W2169741450 @default.
• W2531796630 cites W2187768889 @default.
• W2531796630 cites W2203735107 @default.
• W2531796630 cites W2320807456 @default.
• W2531796630 cites W2334011149 @default.
• W2531796630 cites W2347118546 @default.
• W2531796630 cites W4235271617 @default.
• W2531796630 cites W97175411 @default.
• W2531796630 doi "https://doi.org/10.1038/ncomms13049" @default.
• W2531796630 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5059474" @default.
• W2531796630 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27703167" @default.
• W2531796630 hasPublicationYear "2016" @default.
• W2531796630 type Work @default.
• W2531796630 sameAs 2531796630 @default.
• W2531796630 citedByCount "131" @default.
• W2531796630 countsByYear W25317966302017 @default.
• W2531796630 countsByYear W25317966302018 @default.
• W2531796630 countsByYear W25317966302019 @default.
• W2531796630 countsByYear W25317966302020 @default.
• W2531796630 countsByYear W25317966302021 @default.
• W2531796630 countsByYear W25317966302022 @default.
• W2531796630 countsByYear W25317966302023 @default.
• W2531796630 crossrefType "journal-article" @default.
• W2531796630 hasAuthorship W2531796630A5030568919 @default.
• W2531796630 hasAuthorship W2531796630A5040794773 @default.
• W2531796630 hasAuthorship W2531796630A5056507943 @default.
• W2531796630 hasAuthorship W2531796630A5061702912 @default.
• W2531796630 hasAuthorship W2531796630A5066447821 @default.
• W2531796630 hasAuthorship W2531796630A5075844121 @default.
• W2531796630 hasAuthorship W2531796630A5079006596 @default.
• W2531796630 hasAuthorship W2531796630A5082085789 @default.
• W2531796630 hasAuthorship W2531796630A5090703875 @default.
• W2531796630 hasBestOaLocation W25317966301 @default.
• W2531796630 hasConcept C102744134 @default.
• W2531796630 hasConcept C104317684 @default.
• W2531796630 hasConcept C122917832 @default.
• W2531796630 hasConcept C54355233 @default.
• W2531796630 hasConcept C64894306 @default.
• W2531796630 hasConcept C67705224 @default.
• W2531796630 hasConcept C70721500 @default.
• W2531796630 hasConcept C86803240 @default.
• W2531796630 hasConcept C95444343 @default.
• W2531796630 hasConceptScore W2531796630C102744134 @default.
• W2531796630 hasConceptScore W2531796630C104317684 @default.
• W2531796630 hasConceptScore W2531796630C122917832 @default.

• next