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- W2531850634 abstract "Background & aims Vitamin D (Vit D) deficiency in cystic fibrosis (CF) is partially secondary to exocrine pancreatic insufficiency. Our aim was to establish a Vit D3 supplementation protocol that will increase 25(OH)D to the recommended level (30 ng/mL). Methods Retrospective study of 200 patients (≥18 years) conducted from February 2007 to June 2014 at the CF clinic of the Centre Hospitalier de l’Université de Montréal. Vit D3 supplementation protocol was 1600 IU/day or 10,000 IU/week during the summer (May 1st to October 31st) and 3200 IU/day or 20,000 IU/week during the winter (November 1st to April 30th), in addition to the 1200 IU/day included in multivitamins. Results Significant increase in serum 25(OH)D levels from baseline (25.9 ± 10.3 ng/mL) to follow-up (37.0 ± 11.4 ng/mL) (P ≤ 0.001). At follow-up, increased doses during the winter improved serum 25(OH)D levels to a degree comparable to the summer. Conclusions This supplementation protocol is efficient and needs to be tested in other CF adult cohorts and correlated to potential health benefit measurements." @default.
- W2531850634 created "2016-10-21" @default.
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- W2531850634 date "2017-12-01" @default.
- W2531850634 modified "2023-10-18" @default.
- W2531850634 title "Vitamin D3 supplementation among adult patients with cystic fibrosis" @default.
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- W2531850634 doi "https://doi.org/10.1016/j.clnu.2016.10.002" @default.
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