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- W2531857887 abstract "Galactose-modified thymidine, LNA-T, and 2'-amino-LNA-T nucleosides were synthesized, converted into the corresponding phosphoramidite derivatives and introduced into short oligonucleotides. Compared to the unmodified control strands, the galactose-modified oligonucleotides in general, and the N2'-functionalized 2'-amino-LNA derivatives in particular, showed improved duplex thermal stability against DNA and RNA complements and increased ability to discriminate mismatches. In addition, the 2'-amino-LNA-T derivatives induced remarkable 3'-exonuclease resistance. These results were further investigated using molecular modeling studies." @default.
- W2531857887 created "2016-10-21" @default.
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- W2531857887 date "2016-10-25" @default.
- W2531857887 modified "2023-09-30" @default.
- W2531857887 title "Synthesis and Biophysical Investigations of Oligonucleotides Containing Galactose-Modified DNA, LNA, and 2′-Amino-LNA Monomers" @default.
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- W2531857887 doi "https://doi.org/10.1021/acs.joc.6b01917" @default.
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