Matches in SemOpenAlex for { <https://semopenalex.org/work/W2531892106> ?p ?o ?g. }
- W2531892106 abstract "Abstract Random mutagenesis in a symbiotic nitrogen-fixing Bradyrhizobium liaoningense CCNWSX0360 (Bln0360) using Tn 5 identified five copper (Cu) resistance-related genes. They were functionally sorted into three groups: transmembrane transport ( cueA and tolC ); oxidation ( copA ); and protection of the membrane barrier ( lptE and ctpA ). The gene cueA , together with the upstream csoR (Cu-sensitive operon repressor), constituted a csoR-cueA divergon which plays a crucial role in Cu homeostasis. Deletion of cueA decreased the Cu tolerance of cells, and complementation of this mutant restored comparable Cu resistance to that of the wild-type. Transcriptional and fusion expression analysis demonstrated that csoR-cueA divergon was up-regulated by both the monovalent Cu + and divalent Zn 2+ /Cd 2+ , and negatively regulated by transcriptional repressor CsoR, via a bidirectional promoter. Deletion of csoR renders the cell hyper-resistant to Cu, Zn and Cd. Although predicted to encode a Cu transporting P-type ATPase (CueA), cueA also conferred resistance to zinc and cadmium; two putative N-MBDs (N-terminal metal binding domains) of CueA were required for the Cu/Zn/Cd tolerance. Moreover, cueA is needed for nodulation competitiveness of B. liaoningense in Cu rich conditions. Together, the results demonstrated a crucial role for the csoR-cueA divergon as a component of the multiple-metal resistance machinery in B. liaoningense ." @default.
- W2531892106 created "2016-10-21" @default.
- W2531892106 creator A5015087137 @default.
- W2531892106 creator A5042241749 @default.
- W2531892106 creator A5054691355 @default.
- W2531892106 creator A5066948768 @default.
- W2531892106 creator A5080777603 @default.
- W2531892106 creator A5085769664 @default.
- W2531892106 creator A5089975597 @default.
- W2531892106 date "2016-10-11" @default.
- W2531892106 modified "2023-10-16" @default.
- W2531892106 title "Functional characterization of a csoR-cueA divergon in Bradyrhizobium liaoningense CCNWSX0360, involved in copper, zinc and cadmium cotolerance" @default.
- W2531892106 cites W1542823506 @default.
- W2531892106 cites W1892148740 @default.
- W2531892106 cites W1939143304 @default.
- W2531892106 cites W194917975 @default.
- W2531892106 cites W1963874808 @default.
- W2531892106 cites W1974939001 @default.
- W2531892106 cites W1982424496 @default.
- W2531892106 cites W1987490818 @default.
- W2531892106 cites W1988057243 @default.
- W2531892106 cites W1989133533 @default.
- W2531892106 cites W1996426369 @default.
- W2531892106 cites W2000299318 @default.
- W2531892106 cites W2001151697 @default.
- W2531892106 cites W2006439179 @default.
- W2531892106 cites W2015732828 @default.
- W2531892106 cites W2016719619 @default.
- W2531892106 cites W2021284680 @default.
- W2531892106 cites W2026831681 @default.
- W2531892106 cites W2037444850 @default.
- W2531892106 cites W2044097717 @default.
- W2531892106 cites W2052498582 @default.
- W2531892106 cites W2059073584 @default.
- W2531892106 cites W2061801760 @default.
- W2531892106 cites W2064562224 @default.
- W2531892106 cites W2065035295 @default.
- W2531892106 cites W2073605410 @default.
- W2531892106 cites W2083190918 @default.
- W2531892106 cites W2089391247 @default.
- W2531892106 cites W2090895095 @default.
- W2531892106 cites W2093611074 @default.
- W2531892106 cites W2095816191 @default.
- W2531892106 cites W2097060692 @default.
- W2531892106 cites W2104315311 @default.
- W2531892106 cites W2108846375 @default.
- W2531892106 cites W2109543235 @default.
- W2531892106 cites W2109798934 @default.
- W2531892106 cites W2111747771 @default.
- W2531892106 cites W2112733461 @default.
- W2531892106 cites W2113186717 @default.
- W2531892106 cites W2126309023 @default.
- W2531892106 cites W2127974176 @default.
- W2531892106 cites W2132248680 @default.
- W2531892106 cites W2132591025 @default.
- W2531892106 cites W2157190679 @default.
- W2531892106 cites W2157947524 @default.
- W2531892106 cites W2158937196 @default.
- W2531892106 cites W2164322795 @default.
- W2531892106 cites W2165671141 @default.
- W2531892106 cites W2170053353 @default.
- W2531892106 cites W2170767015 @default.
- W2531892106 cites W367800729 @default.
- W2531892106 doi "https://doi.org/10.1038/srep35155" @default.
- W2531892106 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5057107" @default.
- W2531892106 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27725778" @default.
- W2531892106 hasPublicationYear "2016" @default.
- W2531892106 type Work @default.
- W2531892106 sameAs 2531892106 @default.
- W2531892106 citedByCount "10" @default.
- W2531892106 countsByYear W25318921062019 @default.
- W2531892106 countsByYear W25318921062020 @default.
- W2531892106 countsByYear W25318921062021 @default.
- W2531892106 countsByYear W25318921062022 @default.
- W2531892106 countsByYear W25318921062023 @default.
- W2531892106 crossrefType "journal-article" @default.
- W2531892106 hasAuthorship W2531892106A5015087137 @default.
- W2531892106 hasAuthorship W2531892106A5042241749 @default.
- W2531892106 hasAuthorship W2531892106A5054691355 @default.
- W2531892106 hasAuthorship W2531892106A5066948768 @default.
- W2531892106 hasAuthorship W2531892106A5080777603 @default.
- W2531892106 hasAuthorship W2531892106A5085769664 @default.
- W2531892106 hasAuthorship W2531892106A5089975597 @default.
- W2531892106 hasBestOaLocation W25318921061 @default.
- W2531892106 hasConcept C104317684 @default.
- W2531892106 hasConcept C143065580 @default.
- W2531892106 hasConcept C150194340 @default.
- W2531892106 hasConcept C158448853 @default.
- W2531892106 hasConcept C188082640 @default.
- W2531892106 hasConcept C203075996 @default.
- W2531892106 hasConcept C55493867 @default.
- W2531892106 hasConcept C86803240 @default.
- W2531892106 hasConceptScore W2531892106C104317684 @default.
- W2531892106 hasConceptScore W2531892106C143065580 @default.
- W2531892106 hasConceptScore W2531892106C150194340 @default.
- W2531892106 hasConceptScore W2531892106C158448853 @default.
- W2531892106 hasConceptScore W2531892106C188082640 @default.
- W2531892106 hasConceptScore W2531892106C203075996 @default.
- W2531892106 hasConceptScore W2531892106C55493867 @default.
- W2531892106 hasConceptScore W2531892106C86803240 @default.