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• W2531945396 endingPage "1661" @default.
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• W2531945396 abstract "ABSTRACT During development, cell proliferation and differentiation must be tightly coordinated to ensure proper tissue morphogenesis. Because steroid hormones are central regulators of developmental timing, understanding the links between steroid hormone signaling and cell proliferation is crucial to understanding the molecular basis of morphogenesis. Here we examined the mechanism by which the steroid hormone ecdysone regulates the cell cycle in Drosophila. We find that a cell cycle arrest induced by ecdysone in Drosophila cell culture is analogous to a G2 cell cycle arrest observed in the early pupa wing. We show that in the wing, ecdysone signaling at the larva-to-puparium transition induces Broad which in turn represses the cdc25c phosphatase String. The repression of String generates a temporary G2 arrest that synchronizes the cell cycle in the wing epithelium during early pupa wing elongation and flattening. As ecdysone levels decline after the larva-to-puparium pulse during early metamorphosis, Broad expression plummets, allowing String to become re-activated, which promotes rapid G2/M progression and a subsequent synchronized final cell cycle in the wing. In this manner, pulses of ecdysone can both synchronize the final cell cycle and promote the coordinated acquisition of terminal differentiation characteristics in the wing." @default.
• W2531945396 created "2016-10-21" @default.
• W2531945396 creator A5002078834 @default.
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• W2531945396 date "2016-11-15" @default.
• W2531945396 modified "2023-10-06" @default.
• W2531945396 title "Ecdysone signaling induces two phases of cell cycle exit in<i>Drosophila</i>cells" @default.
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• W2531945396 doi "https://doi.org/10.1242/bio.017525" @default.
• W2531945396 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5155522" @default.
• W2531945396 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27737823" @default.
• W2531945396 hasPublicationYear "2016" @default.
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