FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2531961057> ?p ?o ?g. }

• W2531961057 abstract "Ischemia-reperfusion (I/R) injury often occurs during skin flap transplantation and results in tissue damage. Although estrogen treatment significantly alleviates this I/R injury-induced damage, the detailed molecular mechanism is not clear. In this study, a superficial epigastric artery flap I/R injury model was created in adult Wistar rats. Severe necrosis was observed in skin tissue after I/R injury. Histological examination of skin tissue revealed that I/R injury damages skin structure and results in neutrophil infiltration. Inflammation-related parameters, including neutrophil count, tumor necrosis factor-α, and interleukin-10 levels, were increased due to I/R injury. These pathological phenomena were reduced by estradiol treatment. Further investigation found that I/R injury triggers the p38 mitogen-activated protein kinase (p38-MAPK) pathway. The expression levels of p38-MAPK and phosphorylated p38-MAPK were increased after I/R injury. Estradiol increased the expression level of MAPK phosphatase-2, a putative phosphatase of p38, and reduced the levels of p38-MAPK and phosphorylated p38-MAPK. These results suggest that estradiol can improve skin flap survival, possibly by inhibiting neutrophil infiltration and the expression of p38-MAPK. This study provides an explanation for how estrogen alleviates I/R injury-induced damage that occurs during skin flap transplantation. In a rat pathological model, I/R injury leads to skin necrosis, skin structure damage, neutrophil infiltration, and inflammatory cytokine secretion, which are probably downstream effects of activation of the p38-MAPK pathway. On the other hand, estradiol treatment triggers the expression of MAPK phosphatase-2, a putative phosphatase of p38-MAPK, and reduced all examined pathological phenomena. Therefore, estrogen may reduce the deleterious effect of I/R injury on skin flap transplantation through modulating the p38-MAPK pathway." @default.
• W2531961057 created "2016-10-28" @default.
• W2531961057 creator A5053785414 @default.
• W2531961057 creator A5055745361 @default.
• W2531961057 creator A5069221123 @default.
• W2531961057 date "2016-10-01" @default.
• W2531961057 modified "2023-09-27" @default.
• W2531961057 title "Role of the p38 mitogen-activated protein kinase signaling pathway in estrogen-mediated protection following flap ischemia-reperfusion injury" @default.
• W2531961057 cites W1922653528 @default.
• W2531961057 cites W1965505408 @default.
• W2531961057 cites W1969074099 @default.
• W2531961057 cites W1981459236 @default.
• W2531961057 cites W1988051570 @default.
• W2531961057 cites W1989873586 @default.
• W2531961057 cites W2000015350 @default.
• W2531961057 cites W2004099545 @default.
• W2531961057 cites W2017735744 @default.
• W2531961057 cites W2019358231 @default.
• W2531961057 cites W2023301282 @default.
• W2531961057 cites W2034683922 @default.
• W2531961057 cites W2035192859 @default.
• W2531961057 cites W2037181103 @default.
• W2531961057 cites W2039961443 @default.
• W2531961057 cites W2042921323 @default.
• W2531961057 cites W2046925618 @default.
• W2531961057 cites W2048014052 @default.
• W2531961057 cites W2048150142 @default.
• W2531961057 cites W2057685998 @default.
• W2531961057 cites W2059483934 @default.
• W2531961057 cites W2066793113 @default.
• W2531961057 cites W2072084977 @default.
• W2531961057 cites W2074966179 @default.
• W2531961057 cites W2076252412 @default.
• W2531961057 cites W2080352303 @default.
• W2531961057 cites W2081261193 @default.
• W2531961057 cites W2089267446 @default.
• W2531961057 cites W2098756652 @default.
• W2531961057 cites W2102148097 @default.
• W2531961057 cites W2105571225 @default.
• W2531961057 cites W2109762084 @default.
• W2531961057 cites W2119670701 @default.
• W2531961057 cites W2124722247 @default.
• W2531961057 cites W2133801172 @default.
• W2531961057 cites W2135237689 @default.
• W2531961057 cites W2135417344 @default.
• W2531961057 cites W2144099695 @default.
• W2531961057 cites W2148712853 @default.
• W2531961057 cites W2159203244 @default.
• W2531961057 cites W2191654227 @default.
• W2531961057 cites W2315912140 @default.
• W2531961057 cites W276171312 @default.
• W2531961057 doi "https://doi.org/10.1002/cbf.3226" @default.
• W2531961057 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27748573" @default.
• W2531961057 hasPublicationYear "2016" @default.
• W2531961057 type Work @default.
• W2531961057 sameAs 2531961057 @default.
• W2531961057 citedByCount "5" @default.
• W2531961057 countsByYear W25319610572018 @default.
• W2531961057 countsByYear W25319610572021 @default.
• W2531961057 crossrefType "journal-article" @default.
• W2531961057 hasAuthorship W2531961057A5053785414 @default.
• W2531961057 hasAuthorship W2531961057A5055745361 @default.
• W2531961057 hasAuthorship W2531961057A5069221123 @default.
• W2531961057 hasConcept C121332964 @default.
• W2531961057 hasConcept C126322002 @default.
• W2531961057 hasConcept C134018914 @default.
• W2531961057 hasConcept C142724271 @default.
• W2531961057 hasConcept C153400128 @default.
• W2531961057 hasConcept C17991360 @default.
• W2531961057 hasConcept C184235292 @default.
• W2531961057 hasConcept C2780114680 @default.
• W2531961057 hasConcept C502942594 @default.
• W2531961057 hasConcept C503630168 @default.
• W2531961057 hasConcept C51551487 @default.
• W2531961057 hasConcept C541997718 @default.
• W2531961057 hasConcept C57074206 @default.
• W2531961057 hasConcept C71924100 @default.
• W2531961057 hasConcept C86803240 @default.
• W2531961057 hasConcept C95444343 @default.
• W2531961057 hasConcept C97029542 @default.
• W2531961057 hasConcept C97355855 @default.
• W2531961057 hasConceptScore W2531961057C121332964 @default.
• W2531961057 hasConceptScore W2531961057C126322002 @default.
• W2531961057 hasConceptScore W2531961057C134018914 @default.
• W2531961057 hasConceptScore W2531961057C142724271 @default.
• W2531961057 hasConceptScore W2531961057C153400128 @default.
• W2531961057 hasConceptScore W2531961057C17991360 @default.
• W2531961057 hasConceptScore W2531961057C184235292 @default.
• W2531961057 hasConceptScore W2531961057C2780114680 @default.
• W2531961057 hasConceptScore W2531961057C502942594 @default.
• W2531961057 hasConceptScore W2531961057C503630168 @default.
• W2531961057 hasConceptScore W2531961057C51551487 @default.
• W2531961057 hasConceptScore W2531961057C541997718 @default.
• W2531961057 hasConceptScore W2531961057C57074206 @default.
• W2531961057 hasConceptScore W2531961057C71924100 @default.
• W2531961057 hasConceptScore W2531961057C86803240 @default.
• W2531961057 hasConceptScore W2531961057C95444343 @default.
• W2531961057 hasConceptScore W2531961057C97029542 @default.
• W2531961057 hasConceptScore W2531961057C97355855 @default.
• W2531961057 hasLocation W25319610571 @default.

• next