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• W2532016074 abstract "Lactobacillus species are part of the normal gastrointestinal and female genital tract flora. Although they are generally considered as non-pathogenic, lactobacilli have occasionally been reported as agents of deep infections, for example in oncology, haematology, organ transplant, diabetic, or surgical patients, especially those who are immunosuppressed, or who have received previous antibiotic therapy. 1 Liong M. Safety of probiotics: translocation and infection. Nutr Rev. 2008; 66: 192-202 Crossref PubMed Scopus (170) Google Scholar The Joint Food and Agriculture Organization of the United Nations/World Health Organization Working Group define probiotics as live microbes that confer a benefit on the host. 2 Food and Agriculture Organization of the United Nations/World Health Organization Guidelines for the evaluation of probiotics in food. Joint FAO/WHO Working Group report on drafting guidelines for the evaluation of probiotics in food. Canada, London, Ontario2002 Google Scholar Probiotics including Lactobacillus acidophilus, Lactobacillus rhamnosum, Bifidobacterium bifidum, Bifidobacterium breve, Bifidobacterium infantis, Bifidobacterium longum, Saccharomyces boulardii, and Saccharomyces thermophilus are recognized as food-grade micro-organisms that pose no health risk to healthy consumers. 1 Liong M. Safety of probiotics: translocation and infection. Nutr Rev. 2008; 66: 192-202 Crossref PubMed Scopus (170) Google Scholar , 3 Land M.H. Rouster-Stevens K. Woods C.R. et al. Lactobacillus sepsis associated with probiotic therapy. Pediatrics. 2005; 115: 178-181 Crossref PubMed Scopus (464) Google Scholar , 4 Janvier A. Malo J. Barrington K.J. Cohort study of probiotics in a North American neonatal intensive care unit. J Pediatr. 2014; 5: 981-985 Google Scholar However, there are currently no generally accepted guidelines for the probiotic use in patients who may be at risk of infection with probiotic micro-organisms. 1 Liong M. Safety of probiotics: translocation and infection. Nutr Rev. 2008; 66: 192-202 Crossref PubMed Scopus (170) Google Scholar , 4 Janvier A. Malo J. Barrington K.J. Cohort study of probiotics in a North American neonatal intensive care unit. J Pediatr. 2014; 5: 981-985 Google Scholar Probiotics are increasingly being used to reduce Candida gut colonization in preterm neonates and critically ill children, although not all studies have shown that they are effective. 4 Janvier A. Malo J. Barrington K.J. Cohort study of probiotics in a North American neonatal intensive care unit. J Pediatr. 2014; 5: 981-985 Google Scholar , 5 Honeycutt T. El Khashab M. Wardrop R. et al. Probiotic administration and the incidence of nosocomial infection in pediatric intensive care. A randomized placebo-controlled trial. Pediatr Crit Care Med. 2007; 8: 452-458 Crossref PubMed Scopus (93) Google Scholar Moreover, although probiotics have been reported to be safe in various clinical settings, lactobacilli have been reported to cause sepsis after probiotic administration, especially in children with congenital intestinal anomalies. 3 Land M.H. Rouster-Stevens K. Woods C.R. et al. Lactobacillus sepsis associated with probiotic therapy. Pediatrics. 2005; 115: 178-181 Crossref PubMed Scopus (464) Google Scholar , 4 Janvier A. Malo J. Barrington K.J. Cohort study of probiotics in a North American neonatal intensive care unit. J Pediatr. 2014; 5: 981-985 Google Scholar , 6 Umenai T. Shime N. Asahara T. et al. A pilot study of Bifidobacterium breve in neonates undergoing surgery for congenital heart disease. J Int Crit Care. 2014; 2: 36 PubMed Google Scholar , 7 Banupriya B. Biswal N. Srinivasaraghavan R. et al. Probiotic prophylaxis to prevent ventilator associated pneumonia (VAP) in children on mechanical ventilation: an open-label randomized controlled trial. Int Care Med. 2015; 41: 677-685 Crossref PubMed Scopus (47) Google Scholar , 8 Thompson C. McCarter Y.S. Krause P.J. Herson V.C. Lactobacillus acidophilus sepsis in a neonate. J Perinatol. 2001; 21: 258-260 Crossref PubMed Scopus (70) Google Scholar" @default.
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• W2532016074 title "Lactobacillus casei subsp. rhamnosus septicaemia in three patients of the paediatric intensive care unit" @default.
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