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• W2532082836 abstract "Recruitment methods have demonstrated to influence sample characteristics in Alzheimer Disease (AD) studies [1-5], and there is insufficient information regarding its impact in SCD; therefore our aim is to compare sample characteristics in SCD subjects recruited from two settings: memory unit (MU) vs Open House Initiative (OHI), an activity conducted at Fundacio ACE, where it is offered free cognitive screening to Barcelona citizens. Subjects evaluated at Fundacio ACE between January 2013 and August 2015, who fulfill SCD proposed criteria [6] were selected. It was compared data regarding: age, gender, level of education, familiar history of dementia, personal history of depression, MMSE scores, comprehensive neuropsychological examination, frequency of APOE E4 and amyloid burden measured with (18)F-florbetaben (FBB) PET imaging (when available). A linear regression analysis (LRA), using gender and years of education as covariates were used to examine the neuropsychological variables. 326 subjects were selected: 220 OHI and 106 MU. In comparison with MU sample, OHI were mostly women (75.9%% vs 64.5%], p<0.05), with higher education level (12.15 [3.71] vs 10.70 years [3.80], p=0.001) and more familiar history of dementia (138 [62.7%] vs 44 [41.5%], p<0.001); without statistical significant differences in age or depression history. OHI sample showed better performance in MMSE and neuropsychological tests, except for constructive praxis, verbal long term memory and visual recognition; and after LRA, this this trend continued in automatic response inhibition capacity, abstract reasoning and memory recognition (Table 1). We did not find differences between samples in APOE E4 carriers (one or two alleles) (MU 25.4% vs OHI 24%, p=0.821) or in amyloid burden measured with FBB in 66 subjects (SUVR MU 1.24 vs SUVR OHI 1.18, p=0.551). There were not correlations with the neuropsychological performance and the presence of one or two APOE E4 alleles or the amyloid burden. Subjects with SCD from two samples showed different demographic and neuropsychological characteristics, without significance difference in APOE E4 carriers or in the amyloid burden; and these differences should be considered in the design of SCD's research, to avoid the selection bias that can influence the results and conclusions of these studies." @default.
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• W2532082836 date "2016-07-01" @default.
• W2532082836 modified "2023-10-17" @default.
• W2532082836 title "P1-096: Impact of Recruitment Methods in Subjective Cognitive Decline" @default.
• W2532082836 doi "https://doi.org/10.1016/j.jalz.2016.06.844" @default.
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