FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2532219885> ?p ?o ?g. }

• W2532219885 endingPage "283" @default.
• W2532219885 startingPage "274" @default.
• W2532219885 abstract "Neuroinflammation is a pathological condition that underlies diabetes and affects sensory processing. Given the high prevalence of pain in diabetic patients and crosstalk between chemokines and opioids, it is pivotal to know whether neuroinflammation-associated mediators are dysregulated in the central nervous system of diabetic primates. Therefore, the aim of this study was to investigate whether mRNA expression levels of glial markers, chemokines, and opioid receptors are altered in the spinal cord and thalamus of naturally occurring type 2 diabetic monkeys ( n = 7) compared with age-matched non-diabetic monkeys ( n = 6). By using RT-qPCR, we found that mRNA expression levels of both GFAP and IBA1 were up-regulated in the spinal dorsal horn (SDH) of diabetic monkeys compared with non-diabetic monkeys. Among all chemokines, expression levels of three chemokine ligand-receptor systems, i.e., CCL2-CCR2, CCL3-CCR1/5, and CCL4-CCR5, were up-regulated in the SDH of diabetic monkeys. Moreover, in the SDH, seven additional chemokine receptors, i.e., CCR4, CCR6, CCR8, CCR10, CXCR3, CXCR5, and CXCR6, were also up-regulated in diabetic monkeys. In contrast, expression levels of MOP, KOP, and DOP, but not NOP receptors, were down-regulated in the SDH of diabetic monkeys, and the thalamus had fewer changes in the glial markers, chemokines and opioids. These findings indicate that neuroinflammation, manifested as glial activation and simultaneous up-regulation of multiple chemokine ligands and receptors, seems to be permanent in type 2 diabetic monkeys. As chemokines and opioids are important pain modulators, this first-in-primate study provides a translational bridge for determining the functional efficacy of spinal drugs targeting their signaling cascades. • Astrocytes and microglia are activated in the spinal dorsal horn (SDH) of diabetic monkeys. • Multiple chemokine ligands and receptors (e.g., CCL3-CCR1/5) are simultaneously up-regulated in the SDH of diabetic monkeys. • Opioid receptors, MOP, DOP, KOP, but not NOP receptors, are down-regulated in the SDH of diabetic monkeys. • Ligand-receptor systems as pain modulators in the SDH are more susceptible to changes than in the thalamus of primates. • Neuroinflammation seems to be permanent in the spinal cord of type 2 diabetic monkeys." @default.
• W2532219885 created "2016-10-28" @default.
• W2532219885 creator A5008053293 @default.
• W2532219885 creator A5009653247 @default.
• W2532219885 creator A5029258707 @default.
• W2532219885 creator A5068860618 @default.
• W2532219885 creator A5069088492 @default.
• W2532219885 creator A5070784009 @default.
• W2532219885 creator A5075121265 @default.
• W2532219885 creator A5080747360 @default.
• W2532219885 date "2017-01-01" @default.
• W2532219885 modified "2023-10-17" @default.
• W2532219885 title "Altered expression of glial markers, chemokines, and opioid receptors in the spinal cord of type 2 diabetic monkeys" @default.
• W2532219885 cites W1521031730 @default.
• W2532219885 cites W1532643907 @default.
• W2532219885 cites W1588041244 @default.
• W2532219885 cites W1602835962 @default.
• W2532219885 cites W1763221611 @default.
• W2532219885 cites W1935963841 @default.
• W2532219885 cites W1965942744 @default.
• W2532219885 cites W1966165675 @default.
• W2532219885 cites W1967052683 @default.
• W2532219885 cites W1968709946 @default.
• W2532219885 cites W1976872213 @default.
• W2532219885 cites W1993285878 @default.
• W2532219885 cites W1994752012 @default.
• W2532219885 cites W2001982896 @default.
• W2532219885 cites W2003807844 @default.
• W2532219885 cites W2004035928 @default.
• W2532219885 cites W2006680088 @default.
• W2532219885 cites W2007225703 @default.
• W2532219885 cites W2008628750 @default.
• W2532219885 cites W2017489255 @default.
• W2532219885 cites W2018102225 @default.
• W2532219885 cites W2035415288 @default.
• W2532219885 cites W2035605437 @default.
• W2532219885 cites W2038990149 @default.
• W2532219885 cites W2046296795 @default.
• W2532219885 cites W2051077393 @default.
• W2532219885 cites W2052285428 @default.
• W2532219885 cites W2054586855 @default.
• W2532219885 cites W2055353922 @default.
• W2532219885 cites W2059396054 @default.
• W2532219885 cites W2076869262 @default.
• W2532219885 cites W2081016574 @default.
• W2532219885 cites W2085223462 @default.
• W2532219885 cites W2091978832 @default.
• W2532219885 cites W2092460680 @default.
• W2532219885 cites W2095387649 @default.
• W2532219885 cites W2097529453 @default.
• W2532219885 cites W2103076324 @default.
• W2532219885 cites W2106912151 @default.
• W2532219885 cites W2114570899 @default.
• W2532219885 cites W2116171712 @default.
• W2532219885 cites W2121330782 @default.
• W2532219885 cites W2126709873 @default.
• W2532219885 cites W2126897659 @default.
• W2532219885 cites W2131705782 @default.
• W2532219885 cites W2133108454 @default.
• W2532219885 cites W2134201371 @default.
• W2532219885 cites W2134557769 @default.
• W2532219885 cites W2143413851 @default.
• W2532219885 cites W2144393286 @default.
• W2532219885 cites W2151632825 @default.
• W2532219885 cites W2159125673 @default.
• W2532219885 cites W2169170199 @default.
• W2532219885 cites W2170971994 @default.
• W2532219885 cites W2205880602 @default.
• W2532219885 cites W2234168863 @default.
• W2532219885 cites W2235632662 @default.
• W2532219885 cites W2357660872 @default.
• W2532219885 cites W2418558247 @default.
• W2532219885 cites W2507900361 @default.
• W2532219885 cites W2948665150 @default.
• W2532219885 doi "https://doi.org/10.1016/j.bbadis.2016.10.007" @default.
• W2532219885 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5154845" @default.
• W2532219885 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27751964" @default.
• W2532219885 hasPublicationYear "2017" @default.
• W2532219885 type Work @default.
• W2532219885 sameAs 2532219885 @default.
• W2532219885 citedByCount "19" @default.
• W2532219885 countsByYear W25322198852017 @default.
• W2532219885 countsByYear W25322198852018 @default.
• W2532219885 countsByYear W25322198852019 @default.
• W2532219885 countsByYear W25322198852020 @default.
• W2532219885 countsByYear W25322198852021 @default.
• W2532219885 countsByYear W25322198852022 @default.
• W2532219885 countsByYear W25322198852023 @default.
• W2532219885 crossrefType "journal-article" @default.
• W2532219885 hasAuthorship W2532219885A5008053293 @default.
• W2532219885 hasAuthorship W2532219885A5009653247 @default.
• W2532219885 hasAuthorship W2532219885A5029258707 @default.
• W2532219885 hasAuthorship W2532219885A5068860618 @default.
• W2532219885 hasAuthorship W2532219885A5069088492 @default.
• W2532219885 hasAuthorship W2532219885A5070784009 @default.
• W2532219885 hasAuthorship W2532219885A5075121265 @default.
• W2532219885 hasAuthorship W2532219885A5080747360 @default.
• W2532219885 hasBestOaLocation W25322198852 @default.

• next