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• W2532273158 abstract "Glutamatergic N-methyl-d-aspartate (NMDA) receptors play critical roles in several neurological and psychiatric diseases. Blockade by noncompetitive NMDA receptor antagonist leads to psychotomimetic effects; however, the brain regions responsible for the effects are not well understood. Here, we determined the specific brain regions responsive to MK-801, a noncompetitive NMDA receptor antagonist, by mapping Arc expression as an indicator of neuronal activity using Arc::dVenus reporter mice. MK-801 increased dVenus expression predominantly in the orbitofrontal cortex (OFC) and, as expected, induced a marked hyperlocomotion. Local OFC lesions selectively attenuated the early phase (0–30 min) of MK-801-induced hyperlocomotion. Further, clozapine, an atypical antipsychotic, effectively attenuated both the MK-801-induced dVenus expression in the OFC and hyperlocomotion. These results suggest that the OFC may be critically involved in NMDA receptor-mediated psychotic-like behavioral abnormalities." @default.
• W2532273158 created "2016-10-28" @default.
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• W2532273158 date "2016-11-01" @default.
• W2532273158 modified "2023-09-26" @default.
• W2532273158 title "Critical involvement of the orbitofrontal cortex in hyperlocomotion induced by NMDA receptor blockade in mice" @default.
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• W2532273158 doi "https://doi.org/10.1016/j.bbrc.2016.10.089" @default.
• W2532273158 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27793672" @default.
• W2532273158 hasPublicationYear "2016" @default.
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