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- W2532376319 abstract "HIV causes a severe depletIOn of CD4-posltlve helper T cells, and this predisposes patients to opportUnIstic InfectIOns and malIgnanCies which are the leading reasons for morbidity and mortalIty In AIDS The retrovlral Infection latency and Immunological abnormalIties In patients might be establIshed by the HIV infectIOn of lymphocytes and monocytes/macrophages In vitro vanous compounds have been reported for their ability to inhibit the HIV infectIOn of lymphocytes Among these and In regard of a large broad spectrum, polyoxometalates were evaluated regarding HIV infection inhibitIon Polyoxometalates are polyanIonIc condensed oligomenc aggregates of transltIon metal IOns, held together only by metal oxygen bonds The results of m vitro and m VIVO expenments revealed at least two mechanIsms of actIOn (1) a direct inhibitIOn of one (or more) of the phases of the lentlVlral bIOlogical cycle (binding, fusIOn, RT and RNase actIVIties), (2) a modulatIon of the Immune capaCIties (ADCC and NK functIOns) that might result In an restoratIOn of the defective Immune system of AIDS patients PharmacokInetic studies have been performed In human or non-human pnmates with two compounds HPA-23, and JM-2820 These studies confum (1) the extravascular dlstnbutlOn and (2) the long half-life of the metabolites of two molecules To date, HPA-23 IS the only polyoxo metal ate for which development ended with clInIcal investigatIOn These short-term treatments did not permit to demonstrate any efficacy of m VIVO HPA-23 adminIstratIOn These data constitute pre liminary elements to re-evaluate polyxometalates Indeed, three questIOns remain to be raised (1) duect and/or indirect infectIOn inhibition of macrophages, (2) the modulatIOn of the cytokIne network and (3) the effiCiency of polyoxometalates In long-term treatment" @default.
- W2532376319 created "2016-10-28" @default.
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- W2532376319 date "1994-01-01" @default.
- W2532376319 modified "2023-09-27" @default.
- W2532376319 title "Polyoxometalates III AIDS Therapy" @default.
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- W2532376319 hasPublicationYear "1994" @default.
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