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- W2532438278 abstract "Lamin proteins form a meshwork beneath the nuclear envelope and contribute to many different cellular processes. Mutations in lamins cause defective organogenesis in mouse models and human diseases that affect adipose tissue, brain, skeletal muscle, and the heart. In vitro cell culture studies have shown that lamins help maintain nuclear shape and facilitate cell migration. However, whether these defects contribute to improper tissue building in vivo requires further clarification. By studying the heart epicardium during embryogenesis, we show that Lb1-null epicardial cells exhibit in vivo and in vitro migratory delay. Transcriptome analyses of these cells suggest that Lb1 influences the expression of cell adhesion genes, which could affect cell migration during epicardium development. These epicardial defects are consistent with incomplete development of both vascular smooth muscle and compact myocardium at later developmental stages in Lb1-null embryos. Further, we found that Lb1-null epicardial cells have a delayed nuclear morphology change in vivo, suggesting that Lb1 facilitates morphological changes associated with migration. These findings suggest that Lb1 contributes to nuclear shape maintenance and migration of epicardial cells and highlights the use of these cells for in vitro and in vivo study of these classic cell biological phenomena." @default.
- W2532438278 created "2016-10-28" @default.
- W2532438278 creator A5011101778 @default.
- W2532438278 creator A5075651487 @default.
- W2532438278 creator A5081016920 @default.
- W2532438278 date "2016-12-15" @default.
- W2532438278 modified "2023-10-01" @default.
- W2532438278 title "Lamin-B1 contributes to the proper timing of epicardial cell migration and function during embryonic heart development" @default.
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- W2532438278 doi "https://doi.org/10.1091/mbc.e16-06-0462" @default.
- W2532438278 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5156536" @default.
- W2532438278 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27798236" @default.
- W2532438278 hasPublicationYear "2016" @default.
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