Matches in SemOpenAlex for { <https://semopenalex.org/work/W2532467658> ?p ?o ?g. }
- W2532467658 endingPage "110" @default.
- W2532467658 startingPage "99" @default.
- W2532467658 abstract "Fibrosis is the dramatic consequence of a dysregulated reparative process in which activated fibroblasts (myofibroblasts) and Transforming Growth Factor β1 (TGFβ1) play a central role. When exposed to TGFβ1, fibroblast and epithelial cells differentiate in myofibroblasts; in addition, endothelial cells may undergo endothelial-to-mesenchymal transition (EndoMT) and actively participate to the progression of fibrosis. Recently, the role of αv integrins, which recognize the Arg-Gly-Asp (RGD) tripeptide, in the release and signal transduction activation of TGFβ1 became evident. In this study, we present a class of triazole-derived RGD antagonists that interact with αvβ3 integrin. Above different compounds, the RGD-2 specifically interferes with integrin-dependent TGFβ1 EndoMT in Endothelial Colony-Forming Cells (ECPCs) derived from circulating Endothelial Precursor Cells (ECPCs). The RGD-2 decreases the amount of membrane-associated TGFβ1, and reduces both ALK5/TGFβ1 type I receptor expression and Smad2 phosphorylation in ECPCs. We found that RGD-2 antagonist reverts EndoMT, reducing α-smooth muscle actin (α-SMA) and vimentin expression in differentiated ECPCs. Our results outline the critical role of integrin in fibrosis progression and account for the opportunity of using integrins as target for anti-fibrotic therapeutic treatment." @default.
- W2532467658 created "2016-10-28" @default.
- W2532467658 creator A5016774025 @default.
- W2532467658 creator A5017421300 @default.
- W2532467658 creator A5019631673 @default.
- W2532467658 creator A5033200279 @default.
- W2532467658 creator A5041407933 @default.
- W2532467658 creator A5054034404 @default.
- W2532467658 creator A5066841020 @default.
- W2532467658 creator A5072269563 @default.
- W2532467658 creator A5090108598 @default.
- W2532467658 date "2016-10-19" @default.
- W2532467658 modified "2023-09-23" @default.
- W2532467658 title "Triazole RGD antagonist reverts TGFβ1-induced endothelial-to-mesenchymal transition in endothelial precursor cells" @default.
- W2532467658 cites W1504989678 @default.
- W2532467658 cites W1505584712 @default.
- W2532467658 cites W1520771858 @default.
- W2532467658 cites W1547042245 @default.
- W2532467658 cites W1575754639 @default.
- W2532467658 cites W1702507500 @default.
- W2532467658 cites W1878807841 @default.
- W2532467658 cites W1900328322 @default.
- W2532467658 cites W1931891591 @default.
- W2532467658 cites W1972429412 @default.
- W2532467658 cites W1975142493 @default.
- W2532467658 cites W1978139119 @default.
- W2532467658 cites W1980325398 @default.
- W2532467658 cites W1988613013 @default.
- W2532467658 cites W1995592152 @default.
- W2532467658 cites W1996010478 @default.
- W2532467658 cites W2008204899 @default.
- W2532467658 cites W2022273540 @default.
- W2532467658 cites W2027875827 @default.
- W2532467658 cites W2032487611 @default.
- W2532467658 cites W2037428781 @default.
- W2532467658 cites W2040916923 @default.
- W2532467658 cites W2051910729 @default.
- W2532467658 cites W2052553464 @default.
- W2532467658 cites W2072177520 @default.
- W2532467658 cites W2077090481 @default.
- W2532467658 cites W2089786697 @default.
- W2532467658 cites W2090677926 @default.
- W2532467658 cites W2096879602 @default.
- W2532467658 cites W2101895151 @default.
- W2532467658 cites W2104287544 @default.
- W2532467658 cites W2105231460 @default.
- W2532467658 cites W2106143687 @default.
- W2532467658 cites W2106337175 @default.
- W2532467658 cites W2112195516 @default.
- W2532467658 cites W2115317412 @default.
- W2532467658 cites W2117536783 @default.
- W2532467658 cites W2125227867 @default.
- W2532467658 cites W2130059802 @default.
- W2532467658 cites W2131655610 @default.
- W2532467658 cites W2136005024 @default.
- W2532467658 cites W2138717089 @default.
- W2532467658 cites W2145524503 @default.
- W2532467658 cites W2150548551 @default.
- W2532467658 cites W2152845125 @default.
- W2532467658 cites W2154568166 @default.
- W2532467658 cites W2166874505 @default.
- W2532467658 cites W2167107456 @default.
- W2532467658 cites W4210441984 @default.
- W2532467658 cites W4252346179 @default.
- W2532467658 cites W4254067982 @default.
- W2532467658 doi "https://doi.org/10.1007/s11010-016-2847-2" @default.
- W2532467658 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5219041" @default.
- W2532467658 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27761847" @default.
- W2532467658 hasPublicationYear "2016" @default.
- W2532467658 type Work @default.
- W2532467658 sameAs 2532467658 @default.
- W2532467658 citedByCount "11" @default.
- W2532467658 countsByYear W25324676582018 @default.
- W2532467658 countsByYear W25324676582019 @default.
- W2532467658 countsByYear W25324676582021 @default.
- W2532467658 countsByYear W25324676582023 @default.
- W2532467658 crossrefType "journal-article" @default.
- W2532467658 hasAuthorship W2532467658A5016774025 @default.
- W2532467658 hasAuthorship W2532467658A5017421300 @default.
- W2532467658 hasAuthorship W2532467658A5019631673 @default.
- W2532467658 hasAuthorship W2532467658A5033200279 @default.
- W2532467658 hasAuthorship W2532467658A5041407933 @default.
- W2532467658 hasAuthorship W2532467658A5054034404 @default.
- W2532467658 hasAuthorship W2532467658A5066841020 @default.
- W2532467658 hasAuthorship W2532467658A5072269563 @default.
- W2532467658 hasAuthorship W2532467658A5090108598 @default.
- W2532467658 hasBestOaLocation W25324676581 @default.
- W2532467658 hasConcept C104317684 @default.
- W2532467658 hasConcept C118131993 @default.
- W2532467658 hasConcept C142724271 @default.
- W2532467658 hasConcept C147447768 @default.
- W2532467658 hasConcept C170493617 @default.
- W2532467658 hasConcept C185592680 @default.
- W2532467658 hasConcept C194232998 @default.
- W2532467658 hasConcept C195687474 @default.
- W2532467658 hasConcept C198826908 @default.
- W2532467658 hasConcept C203014093 @default.
- W2532467658 hasConcept C204232928 @default.