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- W2532474489 abstract "The optimization of a palladium-catalyzed Heck–Matsuda reaction using an optimization algorithm is presented. We modified and implemented the Nelder–Mead method in order to perform constrained optimizations in a multidimensional space. We illustrated the power of our modified algorithm through the optimization of a multivariable reaction involving the arylation of a deactivated olefin with an arenediazonium salt. The great flexibility of our optimization method allows to fine-tune experimental conditions according to three different objective functions: maximum yield, highest throughput, and lowest production cost. The beneficial properties of flow reactors associated with the power of intelligent algorithms for the fine-tuning of experimental parameters allowed the reaction to proceed in astonishingly simple conditions unable to promote the coupling through traditional batch chemistry." @default.
- W2532474489 created "2016-10-28" @default.
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- W2532474489 date "2016-10-28" @default.
- W2532474489 modified "2023-10-18" @default.
- W2532474489 title "Optimizing the Heck–Matsuda Reaction in Flow with a Constraint-Adapted Direct Search Algorithm" @default.
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- W2532474489 doi "https://doi.org/10.1021/acs.oprd.6b00310" @default.
- W2532474489 hasPublicationYear "2016" @default.
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