Matches in SemOpenAlex for { <https://semopenalex.org/work/W2532540957> ?p ?o ?g. }
- W2532540957 endingPage "1003" @default.
- W2532540957 startingPage "992" @default.
- W2532540957 abstract "Thymidine phosphorylase (TP, EC 2.4.2.4), an enzyme involved in pyrimidine salvage pathway, is identical to platelet-derived endothelial cell growth factor (PD-ECGF) and gliostatin. It is extremely upregulated in a variety of solid tumours. The TP amplification is associated with concomitant overexpression of many angiogenic factors such as matrix metalloproteases (MMPs), interleukins (ILs), vascular endothelial growth factor (VEGF) etc., resulting in promotion of angiogenesis and cancer metastasis. In addition, overshooting TP level protects tumour cells from apoptosis and helps cell survival. Thus, TP is identified as a prime target for developing novel anticancer therapies. Pioneering research activities investigated a large number of TP inhibitors, most of which are pyrimidine or purine analogues. Recently, an array of structurally diverse non-nucleobase derivatives was designed, synthesized and established as promising TP inhibitors. This review, following an outline on the TP structure and functions, gives an overview of the recent advancement of various non-nucleobase TP inhibitors as novel anti-cancer agents." @default.
- W2532540957 created "2016-10-28" @default.
- W2532540957 creator A5003784039 @default.
- W2532540957 creator A5063344967 @default.
- W2532540957 date "2016-11-01" @default.
- W2532540957 modified "2023-09-25" @default.
- W2532540957 title "Recent discovery of non-nucleobase thymidine phosphorylase inhibitors targeting cancer" @default.
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