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- W2532595958 abstract "Significance LacY catalyzes the coupled transport (symport) of a galactosidic sugar and an H + and is the poster child for the major facilitator superfamily, the largest family of membrane transport proteins. A detailed mechanism has been postulated involving alternating access of sugar- and H + -binding sites to either side of the membrane that is driven by sugar binding and dissociation and independent of the H + electrochemical gradient, which acts kinetically. To characterize structural intermediates in the transport cycle, stable conformers are essential, and camelid single-domain nanobodies (Nbs) are particularly useful in this context. Described herein is a structure of a LacY–Nb complex in which access to the sugar-binding site from the periplasmic cavity is diffusion-limited." @default.
- W2532595958 created "2016-10-28" @default.
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- W2532595958 date "2016-10-19" @default.
- W2532595958 modified "2023-10-18" @default.
- W2532595958 title "Crystal structure of a LacY–nanobody complex in a periplasmic-open conformation" @default.
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- W2532595958 doi "https://doi.org/10.1073/pnas.1615414113" @default.
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