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- W2532925219 abstract "Background: Cellular stress during reoxygenation is a common phenomenon in solid organ transplantation and is characterized by production of reactive oxygen species and free radicals. Herein, we studied in isolated tubular segments (ITS) of rat kidney cortex the impact of hemoglobin (Hb), oxygen radical scavengers and an iron chelator on post-hypoxic recovery. Methods: Tubules, suspended in Ringer’s solution containing 5 mM glycine, underwent 30 min hypoxia and 60 min reoxygenation, untreated tubules served as controls. Different concentrations of free Hb and equivalent amounts of intact erythrocytes were added to the incubation medium. Hypoxia/reoxygenation injury was measured by membrane leakage, lipid peroxidation and cellular functions. In hypoxia/reoxygenated ITS, protective effects of different scavengers and of the iron chelator deferoxamine (DFO) on hypoxia/reoxygenation injury were analyzed. Results: Hb exerted concentration-dependent cytotoxic effects indicated by significantly decreased cell function (P < 0.05), in ITS during hypoxia, and subsequent reoxygenation. Scavengers protected ITS from hypoxia/reoxygenation-induced cellular disintegration and dysfunction, whereas DFO was found to exert the most distinct protection. DFO was further found to exert a dose-dependent protection on hypoxia/ reoxygenation damage in ITS which was critically mediated by chelating tissue and hemoglobin-bond iron ions. Conclusions: Our data demonstrate, that radical scavengers effectively protect from hypoxia/reoxygenation injury in ITS, and that especially the iron chelator DFO is a potent inhibitor of iron ion-mediated hypoxia/reoxygenation damage. Thus, inclusion of antioxidants and iron chelators in organ storage solutions might improve post-transplant organ function and protect from reperfusion injury." @default.
- W2532925219 created "2016-10-28" @default.
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- W2532925219 date "2008-01-01" @default.
- W2532925219 modified "2023-09-27" @default.
- W2532925219 title "Die durch freies Hämoglobin verursachten zytotoxischen Schäden in glycingeschützten Tubuluszellen der Niere können durch Radikalfänger und DFO vermindert werden Hemoglobin caused post-hypoxic cellular disintegration in glycine-preserved renal tubules is attenuated by OH . radical scavengers and iron chelators" @default.
- W2532925219 cites W2033139000 @default.
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- W2532925219 hasPublicationYear "2008" @default.
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