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- W2532947584 abstract "Mild cognitive impairment (MCI) is a risk factor for dementia, although not all progress to dementia and many revert to normal cognition (NC). Incidence rates of MCI are not well described and conversion rates vary widely. We examined MCI incidence, stability and conversion to dementia over 6 years in 873 community dwelling non-demented older adults aged 70-90 years at baseline. MCI was diagnosed by neuropsychological tests of memory, language, visuospatial, attention/processing speed and executive functioning. Cognitive and functional measures were collected at baseline, 2, 4 and 6 years. MCI and dementia were diagnosed according to established criteria. We defined “Incident MCI” as NC participants at baseline who had MCI at waves 2, 3 or 4; and “Unstable MCI” as MCI at baseline which reverted to NC≥1 over follow-up. Of 873 participants included at baseline, 474 had complete follow-up data. At 6 years, 114 (13%) had died and 285 (33%) were missing cognitive data at least once. At baseline 66% (313/474) had NC and 34% (161/474) had MCI. The rate of incident MCI was 38% (119/313) of whom 39% (47/119) reverted to NC at least once during follow-up. Over the six years, 39% (187/474) were stable NC at all 4 waves, 11% (54/474) were stable MCI, 11% (53/474) incident dementia, 22% incident MCI no dementia (105/474) and 16% (75/474) were unstable MCI. Conversion to dementia was 4% from NC (7/194). Conversion to dementia did not differ between incident MCI (12%) and baseline MCI (20%) (X2(1) = 3.3, p =.07). However, when unstable MCI cases were removed, the rate of dementia was higher amongst baseline MCI (36%) than stable incident MCI (20%) (X2(1) = 5.1, p <.01). Overall incident MCI was high in this community sample (38%). The natural history of MCI varies, with different rates of progression to dementia depending on the length and stability of the diagnosis." @default.
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- W2532947584 date "2016-07-01" @default.
- W2532947584 modified "2023-10-18" @default.
- W2532947584 title "P1-388: Incidence of MCI and Dementia Over Six Years in an Australian Population Sample" @default.
- W2532947584 doi "https://doi.org/10.1016/j.jalz.2016.06.1140" @default.
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