FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2532958414> ?p ?o ?g. }

• W2532958414 endingPage "403" @default.
• W2532958414 startingPage "397" @default.
• W2532958414 abstract "Summary Functional genetic polymorphisms that altered gene expression of cytokines are candidate genetic factors that could modulate the development and progression of Hashimoto's thyroiditis ( HT ). IL ‐12B gene encoded the IL ‐12p40 subunit, which is included in the pro‐inflammatory heterodimeric cytokines IL ‐12p70 and IL ‐23. IL ‐10 is an important Treg cytokine suppressing inflammatory cytokine production and autoimmunity. This study was designed to compare −1082A/ GIL ‐10 and +1188A/C3′ UTRIL ‐12B genotype distribution in 130 patients with HT to a group of 157 healthy controls in attempts to determine an association with HT development. Genotyping for the 3′ UTRA /C IL ‐12B polymorphism was performed using RFLP ‐ PCR and genotyping for −1082A/G IL ‐10 by ARMS ‐ PCR assay. Patients with HT were divided into euthyroid and hypothyroid stages. There were no significant differences in the genotype and allele frequencies of the IL ‐12B polymorphism between patients with HT and controls. We observed higher euthyroid HT risk for individuals with CC genotype, unlike to develop hypothyroidism with OR = 1.68. Regarding the polymorphism rs1800896, it was shown the significantly higher frequency of homozygous genotype GG in cases vs controls ( OR = 2.19; P = 0.024). Moreover, the combination of genotype AA of 3′ UTRIL ‐12B with GG of −1082 IL ‐10 was associated with a threefold increasing risk ( OR = 3.188; P = 0.022) of developing HT compared to individuals with the presence of 3′ UTR allele C ( AC + CC ) simultaneously with AA genotype of −1082 IL ‐10. Our data raise the possibility that the combined effect of polymorphisms from proinflammatory and anti‐inflammatory cytokines may be more decisive to HT development." @default.
• W2532958414 created "2016-10-28" @default.
• W2532958414 creator A5012263221 @default.
• W2532958414 creator A5083392735 @default.
• W2532958414 date "2016-10-24" @default.
• W2532958414 modified "2023-09-27" @default.
• W2532958414 title "IL-12B and IL-10 gene polymorphisms in the development of Hashimoto's thyroiditis" @default.
• W2532958414 cites W1499666021 @default.
• W2532958414 cites W1541670683 @default.
• W2532958414 cites W1585477246 @default.
• W2532958414 cites W1961628794 @default.
• W2532958414 cites W1968918322 @default.
• W2532958414 cites W1971413597 @default.
• W2532958414 cites W1981037313 @default.
• W2532958414 cites W1994096272 @default.
• W2532958414 cites W2001027202 @default.
• W2532958414 cites W2005074729 @default.
• W2532958414 cites W2006562831 @default.
• W2532958414 cites W2006619058 @default.
• W2532958414 cites W2009219530 @default.
• W2532958414 cites W2013948033 @default.
• W2532958414 cites W2029419206 @default.
• W2532958414 cites W2030505452 @default.
• W2532958414 cites W2033998941 @default.
• W2532958414 cites W2043372180 @default.
• W2532958414 cites W2063336961 @default.
• W2532958414 cites W2073146016 @default.
• W2532958414 cites W2076889715 @default.
• W2532958414 cites W2078956320 @default.
• W2532958414 cites W2108400189 @default.
• W2532958414 cites W2118512649 @default.
• W2532958414 cites W2120083035 @default.
• W2532958414 cites W2136718097 @default.
• W2532958414 cites W2161074777 @default.
• W2532958414 cites W2322229996 @default.
• W2532958414 cites W249403745 @default.
• W2532958414 cites W391990081 @default.
• W2532958414 doi "https://doi.org/10.1111/iji.12293" @default.
• W2532958414 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27774749" @default.
• W2532958414 hasPublicationYear "2016" @default.
• W2532958414 type Work @default.
• W2532958414 sameAs 2532958414 @default.
• W2532958414 citedByCount "6" @default.
• W2532958414 countsByYear W25329584142018 @default.
• W2532958414 countsByYear W25329584142019 @default.
• W2532958414 countsByYear W25329584142020 @default.
• W2532958414 countsByYear W25329584142022 @default.
• W2532958414 crossrefType "journal-article" @default.
• W2532958414 hasAuthorship W2532958414A5012263221 @default.
• W2532958414 hasAuthorship W2532958414A5083392735 @default.
• W2532958414 hasConcept C104317684 @default.
• W2532958414 hasConcept C126322002 @default.
• W2532958414 hasConcept C135763542 @default.
• W2532958414 hasConcept C149737253 @default.
• W2532958414 hasConcept C180754005 @default.
• W2532958414 hasConcept C203014093 @default.
• W2532958414 hasConcept C2777195454 @default.
• W2532958414 hasConcept C2778690821 @default.
• W2532958414 hasConcept C2778696486 @default.
• W2532958414 hasConcept C31467283 @default.
• W2532958414 hasConcept C37463918 @default.
• W2532958414 hasConcept C526584372 @default.
• W2532958414 hasConcept C54355233 @default.
• W2532958414 hasConcept C67636389 @default.
• W2532958414 hasConcept C68239362 @default.
• W2532958414 hasConcept C71924100 @default.
• W2532958414 hasConcept C86803240 @default.
• W2532958414 hasConceptScore W2532958414C104317684 @default.
• W2532958414 hasConceptScore W2532958414C126322002 @default.
• W2532958414 hasConceptScore W2532958414C135763542 @default.
• W2532958414 hasConceptScore W2532958414C149737253 @default.
• W2532958414 hasConceptScore W2532958414C180754005 @default.
• W2532958414 hasConceptScore W2532958414C203014093 @default.
• W2532958414 hasConceptScore W2532958414C2777195454 @default.
• W2532958414 hasConceptScore W2532958414C2778690821 @default.
• W2532958414 hasConceptScore W2532958414C2778696486 @default.
• W2532958414 hasConceptScore W2532958414C31467283 @default.
• W2532958414 hasConceptScore W2532958414C37463918 @default.
• W2532958414 hasConceptScore W2532958414C526584372 @default.
• W2532958414 hasConceptScore W2532958414C54355233 @default.
• W2532958414 hasConceptScore W2532958414C67636389 @default.
• W2532958414 hasConceptScore W2532958414C68239362 @default.
• W2532958414 hasConceptScore W2532958414C71924100 @default.
• W2532958414 hasConceptScore W2532958414C86803240 @default.
• W2532958414 hasIssue "6" @default.
• W2532958414 hasLocation W25329584141 @default.
• W2532958414 hasLocation W25329584142 @default.
• W2532958414 hasOpenAccess W2532958414 @default.
• W2532958414 hasPrimaryLocation W25329584141 @default.
• W2532958414 hasRelatedWork W2004355765 @default.
• W2532958414 hasRelatedWork W2020364677 @default.
• W2532958414 hasRelatedWork W2051135531 @default.
• W2532958414 hasRelatedWork W2353742692 @default.
• W2532958414 hasRelatedWork W2378768101 @default.
• W2532958414 hasRelatedWork W2386446805 @default.
• W2532958414 hasRelatedWork W2532958414 @default.
• W2532958414 hasRelatedWork W2789624456 @default.
• W2532958414 hasRelatedWork W2810362112 @default.

• next