FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2532969254> ?p ?o ?g. }

• W2532969254 endingPage "387" @default.
• W2532969254 startingPage "379" @default.
• W2532969254 abstract "As it is a hard-wired system for responses to microbes, innate immunity is particularly susceptible to classical genetic analysis. Mutations led the way to the discovery of many of the molecular elements of innate immune sensing and signaling pathways. In turn, the need for a faster way to find the molecular causes of mutation-induced phenotypes triggered a huge transformation in forward genetics. During the 1980s and 1990s, many heritable phenotypes were ascribed to mutations through positional cloning. In mice, this required three steps. First, a genetic mapping step was used to show that a given phenotype emanated from a circumscribed region of the genome. Second, a physical mapping step was undertaken, in which all of the region was cloned and its gene content determined. Finally, a concerted search for the mutation was performed. Such projects usually lasted for several years, but could produce breakthroughs in our understanding of biological processes. Publication of the annotated mouse genome sequence in 2002 made physical mapping unnecessary. More recently we devised a new technology for automated genetic mapping, which eliminated both genetic mapping and the search for mutations among candidate genes. The cause of phenotype can now be determined instantaneously. We have created more than 100,000 coding/splicing mutations. And by screening for defects of innate and adaptive immunity we have discovered many “new” proteins needed for innate immune function." @default.
• W2532969254 created "2016-10-28" @default.
• W2532969254 creator A5059140393 @default.
• W2532969254 date "2016-12-01" @default.
• W2532969254 modified "2023-10-09" @default.
• W2532969254 title "Innate immunity and the new forward genetics" @default.
• W2532969254 cites W125387947 @default.
• W2532969254 cites W1551766403 @default.
• W2532969254 cites W1559742681 @default.
• W2532969254 cites W1563615273 @default.
• W2532969254 cites W1565635064 @default.
• W2532969254 cites W1584403537 @default.
• W2532969254 cites W1836427129 @default.
• W2532969254 cites W1969697265 @default.
• W2532969254 cites W1971308951 @default.
• W2532969254 cites W1972437692 @default.
• W2532969254 cites W1977248022 @default.
• W2532969254 cites W1987410025 @default.
• W2532969254 cites W1988120605 @default.
• W2532969254 cites W1992494470 @default.
• W2532969254 cites W1994838976 @default.
• W2532969254 cites W1996713062 @default.
• W2532969254 cites W1997977259 @default.
• W2532969254 cites W1999102617 @default.
• W2532969254 cites W2002005510 @default.
• W2532969254 cites W2014753302 @default.
• W2532969254 cites W2027816595 @default.
• W2532969254 cites W2035578557 @default.
• W2532969254 cites W2039599894 @default.
• W2532969254 cites W2042854868 @default.
• W2532969254 cites W2049874360 @default.
• W2532969254 cites W2049914201 @default.
• W2532969254 cites W2051039710 @default.
• W2532969254 cites W2062016633 @default.
• W2532969254 cites W2066080768 @default.
• W2532969254 cites W2069663822 @default.
• W2532969254 cites W2071100300 @default.
• W2532969254 cites W2074534029 @default.
• W2532969254 cites W2078078890 @default.
• W2532969254 cites W2079462606 @default.
• W2532969254 cites W2087311380 @default.
• W2532969254 cites W2089496298 @default.
• W2532969254 cites W2090421407 @default.
• W2532969254 cites W21036275 @default.
• W2532969254 cites W2108843246 @default.
• W2532969254 cites W2109337455 @default.
• W2532969254 cites W2116883279 @default.
• W2532969254 cites W2118526609 @default.
• W2532969254 cites W2121642311 @default.
• W2532969254 cites W2125391335 @default.
• W2532969254 cites W2128440643 @default.
• W2532969254 cites W2129319296 @default.
• W2532969254 cites W2139299700 @default.
• W2532969254 cites W2150576092 @default.
• W2532969254 cites W2151464048 @default.
• W2532969254 cites W2169484283 @default.
• W2532969254 cites W2170920726 @default.
• W2532969254 cites W2613631650 @default.
• W2532969254 cites W2761988543 @default.
• W2532969254 cites W316274346 @default.
• W2532969254 cites W4299887572 @default.
• W2532969254 cites W4313310058 @default.
• W2532969254 doi "https://doi.org/10.1016/j.beha.2016.10.018" @default.
• W2532969254 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5179328" @default.
• W2532969254 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27890263" @default.
• W2532969254 hasPublicationYear "2016" @default.
• W2532969254 type Work @default.
• W2532969254 sameAs 2532969254 @default.
• W2532969254 citedByCount "6" @default.
• W2532969254 countsByYear W25329692542019 @default.
• W2532969254 countsByYear W25329692542020 @default.
• W2532969254 crossrefType "journal-article" @default.
• W2532969254 hasAuthorship W2532969254A5059140393 @default.
• W2532969254 hasBestOaLocation W25329692542 @default.
• W2532969254 hasConcept C104317684 @default.
• W2532969254 hasConcept C127716648 @default.
• W2532969254 hasConcept C134486438 @default.
• W2532969254 hasConcept C136449434 @default.
• W2532969254 hasConcept C141231307 @default.
• W2532969254 hasConcept C193419808 @default.
• W2532969254 hasConcept C207177822 @default.
• W2532969254 hasConcept C3020804800 @default.
• W2532969254 hasConcept C501734568 @default.
• W2532969254 hasConcept C54355233 @default.
• W2532969254 hasConcept C70721500 @default.
• W2532969254 hasConcept C86803240 @default.
• W2532969254 hasConcept C8891405 @default.
• W2532969254 hasConceptScore W2532969254C104317684 @default.
• W2532969254 hasConceptScore W2532969254C127716648 @default.
• W2532969254 hasConceptScore W2532969254C134486438 @default.
• W2532969254 hasConceptScore W2532969254C136449434 @default.
• W2532969254 hasConceptScore W2532969254C141231307 @default.
• W2532969254 hasConceptScore W2532969254C193419808 @default.
• W2532969254 hasConceptScore W2532969254C207177822 @default.
• W2532969254 hasConceptScore W2532969254C3020804800 @default.
• W2532969254 hasConceptScore W2532969254C501734568 @default.
• W2532969254 hasConceptScore W2532969254C54355233 @default.
• W2532969254 hasConceptScore W2532969254C70721500 @default.

• next