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- W2532983290 abstract "Chronic intermittent hypoxia (CIH) and hypertension are closely related conditions. In studies performed with animal models of CIH, antihypertensive drugs were just used as pharmacological tools and the experiments were not planned to first induce hypertension and further evaluate the efficacy of drugs. We aimed to investigate in a rat model of CIH-induced hypertension, the efficacy of three different doses of carvedilol, a nonselective beta-blocker with intrinsic anti- α1-adrenergic activity. Experiments were performed in 31 male Wistar rats, aged 2-3 months, with mean body weight 308.4±45.36 g. Rats were housed individually with indwelling blood pressure telemeters and the cages were kept in a atmosphere controlled by an OxyCycler AT series, which gradually lowered oxygen in the chamber from 21% to 5% O 2 . Animals were exposed during their sleep period to 5.6 CIH cycles/h, 10.5 h/day, for 60 days. Carvedilol administration, by gavage, started at day 36 of CIH period and lasted 25 days. Statistical significance for all tests was set at the level of p" @default.
- W2532983290 created "2016-10-28" @default.
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- W2532983290 date "2015-09-01" @default.
- W2532983290 modified "2023-09-22" @default.
- W2532983290 title "Hypertension induced by chronic intermittent hypoxia: Effects of carvedilol in a rat model" @default.
- W2532983290 doi "https://doi.org/10.1183/13993003.congress-2015.oa294" @default.
- W2532983290 hasPublicationYear "2015" @default.
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