FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2533078052> ?p ?o ?g. }

• W2533078052 endingPage "226" @default.
• W2533078052 startingPage "187" @default.
• W2533078052 abstract "The condensation and aggregation of individual protein molecules into dense insoluble phases is of relevance in such diverse fields as materials science, medicine, structural biology and pharmacology. A common feature of these condensation phenomena is that they usually are nucleated processes, i.e. the first piece of the condensed phase is energetically costly to create and hence forms slowly compared to its subsequent growth. Here we give a compact overview of the differences and similarities of various protein nucleation phenomena, their theoretical description in the framework of colloid and polymer science and their experimental study. Particular emphasis is put on the nucleation of a specific type of filamentous protein aggregates, amyloid fibrils. The current experimentally derived knowledge on amyloid fibril nucleation is critically assessed, and we argue that it is less advanced than is generally believed. This is due to (I) the lack of emphasis that has been put on the distinction between homogeneous and heterogeneous nucleation in experimental studies (II) the use of oversimplifying and/or inappropriate theoretical frameworks for the analysis of kinetic data of amyloid fibril nucleation. A strategy is outlined and advocated of how our understanding of this important class of processes can be improved in the future." @default.
• W2533078052 created "2016-10-28" @default.
• W2533078052 creator A5006551440 @default.
• W2533078052 date "2017-01-01" @default.
• W2533078052 modified "2023-09-26" @default.
• W2533078052 title "The Nucleation of Protein Aggregates - From Crystals to Amyloid Fibrils" @default.
• W2533078052 cites W1487789916 @default.
• W2533078052 cites W1587588813 @default.
• W2533078052 cites W1601410431 @default.
• W2533078052 cites W1912455695 @default.
• W2533078052 cites W1929166955 @default.
• W2533078052 cites W1952608303 @default.
• W2533078052 cites W1965152382 @default.
• W2533078052 cites W1967284319 @default.
• W2533078052 cites W1967364087 @default.
• W2533078052 cites W1967440363 @default.
• W2533078052 cites W1968466264 @default.
• W2533078052 cites W1968509046 @default.
• W2533078052 cites W1968778374 @default.
• W2533078052 cites W1969699861 @default.
• W2533078052 cites W1970577444 @default.
• W2533078052 cites W1979355017 @default.
• W2533078052 cites W1980074085 @default.
• W2533078052 cites W1980850794 @default.
• W2533078052 cites W1981789517 @default.
• W2533078052 cites W1983254345 @default.
• W2533078052 cites W1986869100 @default.
• W2533078052 cites W1989808640 @default.
• W2533078052 cites W1989957198 @default.
• W2533078052 cites W1990592765 @default.
• W2533078052 cites W1991659188 @default.
• W2533078052 cites W1992053868 @default.
• W2533078052 cites W1995394213 @default.
• W2533078052 cites W1995442956 @default.
• W2533078052 cites W1997762479 @default.
• W2533078052 cites W1998034408 @default.
• W2533078052 cites W2000036069 @default.
• W2533078052 cites W2001270910 @default.
• W2533078052 cites W2003623645 @default.
• W2533078052 cites W2004098528 @default.
• W2533078052 cites W2004176946 @default.
• W2533078052 cites W2005212584 @default.
• W2533078052 cites W2005279391 @default.
• W2533078052 cites W2007487406 @default.
• W2533078052 cites W2007523574 @default.
• W2533078052 cites W2007593295 @default.
• W2533078052 cites W2007603595 @default.
• W2533078052 cites W2007796463 @default.
• W2533078052 cites W2012455318 @default.
• W2533078052 cites W2012561243 @default.
• W2533078052 cites W2013112316 @default.
• W2533078052 cites W2013455144 @default.
• W2533078052 cites W2015092927 @default.
• W2533078052 cites W2016819659 @default.
• W2533078052 cites W2024420279 @default.
• W2533078052 cites W2024691049 @default.
• W2533078052 cites W2027398076 @default.
• W2533078052 cites W2030325989 @default.
• W2533078052 cites W2034887565 @default.
• W2533078052 cites W2035547974 @default.
• W2533078052 cites W2039003502 @default.
• W2533078052 cites W2041669759 @default.
• W2533078052 cites W2043833442 @default.
• W2533078052 cites W2044246569 @default.
• W2533078052 cites W2045541909 @default.
• W2533078052 cites W2049421402 @default.
• W2533078052 cites W2049827200 @default.
• W2533078052 cites W2050375429 @default.
• W2533078052 cites W2051436893 @default.
• W2533078052 cites W2054868321 @default.
• W2533078052 cites W2056785199 @default.
• W2533078052 cites W2057168246 @default.
• W2533078052 cites W2057673048 @default.
• W2533078052 cites W2060159611 @default.
• W2533078052 cites W2060594859 @default.
• W2533078052 cites W2061657038 @default.
• W2533078052 cites W2063827082 @default.
• W2533078052 cites W2064581913 @default.
• W2533078052 cites W2064677495 @default.
• W2533078052 cites W2066214505 @default.
• W2533078052 cites W2066334438 @default.
• W2533078052 cites W2067924797 @default.
• W2533078052 cites W2069350490 @default.
• W2533078052 cites W2070905182 @default.
• W2533078052 cites W2071466044 @default.
• W2533078052 cites W2072090189 @default.
• W2533078052 cites W2072675976 @default.
• W2533078052 cites W2073449985 @default.
• W2533078052 cites W2073618322 @default.
• W2533078052 cites W2075944712 @default.
• W2533078052 cites W2076351952 @default.
• W2533078052 cites W2078450707 @default.
• W2533078052 cites W2080225612 @default.
• W2533078052 cites W2084141530 @default.
• W2533078052 cites W2085687763 @default.
• W2533078052 cites W2085899859 @default.
• W2533078052 cites W2087794984 @default.
• W2533078052 cites W2090542102 @default.

• next