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• W2533105700 abstract "As the main bioactive component of Chinese herbal medicine Danshen, salvianolic acid B (Sal B, or lithospermic acid B) was observed to maintain the viability of mesenchymal stem cells (MSCs) treated by Fenton's reagent in the study. Interestingly, at a higher concentration, Sal B could even increase the viability rate to 175.1%. In mechanistic analysis experiments, Sal B was found to resist DNA destruction by •OH radical, scavenge various radicals in vitro, reduce Cu2+ → Cu+, chelate Fe2+ to yield an absorption maximum at 710 nm. Based on these results, we concluded that, (1) Sal B can not only protect MSCs against •OH-induced damages, but also promote their proliferation. This extraordinary capacity makes Sal B an ideal candidate in MSCs transplantation especially when MSCs are polluted by iron-overload or other oxidative stress factors and, can partly be responsible for the versatile properties of Sal B in pharmacology. The possible mechanisms of its protective effect are hypothesized to include Fe2+ chelating, and direct radical scavenging which is involved in electron transfer (ET) or hydrogen atom transfer (HAT) from the catechol moieties. Its proliferation-promoting effect is presumed to be from its ester group, carboxylic group, or benzofuran ring." @default.
• W2533105700 created "2016-10-28" @default.
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• W2533105700 date "2016-10-11" @default.
• W2533105700 modified "2023-10-12" @default.
• W2533105700 title "Mechanistic Chemistry of Extraordinary Capacity of Salvianolic Acid B on Oxidatively-damaged Mesenchymal Stem Cells" @default.
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• W2533105700 doi "https://doi.org/10.1002/jccs.201600112" @default.
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