Matches in SemOpenAlex for { <https://semopenalex.org/work/W2533353513> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2533353513 abstract "A new series of 2-substituted-3-allyl-4(3H)-quinazolinone derivatives (4a-e-8a-d) were synthesized and evaluated for their anticonvulsant activity against pentylenetetrazole (PTZ)-induced seizures and maximal electroshock test in mice and compared with the reference drugs methaqualone and sodium valproate. The neurotoxicity was assessed using rotarod test. The molecular modeling was performed for all synthesized compounds to predict their binding affinity towards GABA-A receptor as a proposed mode of their anticonvulsant activity. The data obtained from the molecular docking was strongly correlated with that obtained from the biological screening which revealed that; compounds 4c, 4b and 4d showed the highest binding affinities towards GABA-A receptor and also showed the highest anticonvulsant activities in experimental mice with relatively low neurotoxicity and low toxicity in the median lethal dose test when compared with the reference drugs. The obtained results proved that the most active compounds could be useful as a model for future design, adaptation and investigation to construct more active analogs." @default.
- W2533353513 created "2016-10-28" @default.
- W2533353513 creator A5010197883 @default.
- W2533353513 creator A5030651457 @default.
- W2533353513 creator A5031952304 @default.
- W2533353513 creator A5066270766 @default.
- W2533353513 date "2016-01-01" @default.
- W2533353513 modified "2023-10-17" @default.
- W2533353513 title "Molecular Docking, Synthesis and Biological Evaluation of Some Novel 2-Substituted-3-allyl-4(3H)-quinazolinone Derivatives as Anticonvulsant Agents" @default.
- W2533353513 cites W1525713084 @default.
- W2533353513 cites W1970099699 @default.
- W2533353513 cites W1974818478 @default.
- W2533353513 cites W1992363137 @default.
- W2533353513 cites W1997967494 @default.
- W2533353513 cites W2010870547 @default.
- W2533353513 cites W2017455957 @default.
- W2533353513 cites W2018021139 @default.
- W2533353513 cites W2021137848 @default.
- W2533353513 cites W2030413055 @default.
- W2533353513 cites W2038331446 @default.
- W2533353513 cites W2050094354 @default.
- W2533353513 cites W2055363364 @default.
- W2533353513 cites W2056945518 @default.
- W2533353513 cites W2065457701 @default.
- W2533353513 cites W2083038332 @default.
- W2533353513 cites W2083322751 @default.
- W2533353513 cites W2091874844 @default.
- W2533353513 cites W2093022342 @default.
- W2533353513 cites W2093472798 @default.
- W2533353513 cites W2100300115 @default.
- W2533353513 cites W2118632772 @default.
- W2533353513 cites W2179088208 @default.
- W2533353513 cites W2243485378 @default.
- W2533353513 cites W2327954914 @default.
- W2533353513 cites W2415541351 @default.
- W2533353513 cites W2498454626 @default.
- W2533353513 cites W3080277621 @default.
- W2533353513 cites W626165592 @default.
- W2533353513 cites W769198293 @default.
- W2533353513 doi "https://doi.org/10.4172/2161-0444.1000404" @default.
- W2533353513 hasPublicationYear "2016" @default.
- W2533353513 type Work @default.
- W2533353513 sameAs 2533353513 @default.
- W2533353513 citedByCount "9" @default.
- W2533353513 countsByYear W25333535132017 @default.
- W2533353513 countsByYear W25333535132018 @default.
- W2533353513 countsByYear W25333535132019 @default.
- W2533353513 countsByYear W25333535132020 @default.
- W2533353513 countsByYear W25333535132022 @default.
- W2533353513 countsByYear W25333535132023 @default.
- W2533353513 crossrefType "journal-article" @default.
- W2533353513 hasAuthorship W2533353513A5010197883 @default.
- W2533353513 hasAuthorship W2533353513A5030651457 @default.
- W2533353513 hasAuthorship W2533353513A5031952304 @default.
- W2533353513 hasAuthorship W2533353513A5066270766 @default.
- W2533353513 hasBestOaLocation W25333535131 @default.
- W2533353513 hasConcept C159110408 @default.
- W2533353513 hasConcept C169760540 @default.
- W2533353513 hasConcept C185592680 @default.
- W2533353513 hasConcept C21951064 @default.
- W2533353513 hasConcept C2775858608 @default.
- W2533353513 hasConcept C2777162773 @default.
- W2533353513 hasConcept C2778186239 @default.
- W2533353513 hasConcept C41685203 @default.
- W2533353513 hasConcept C71240020 @default.
- W2533353513 hasConcept C71924100 @default.
- W2533353513 hasConcept C86803240 @default.
- W2533353513 hasConcept C98274493 @default.
- W2533353513 hasConceptScore W2533353513C159110408 @default.
- W2533353513 hasConceptScore W2533353513C169760540 @default.
- W2533353513 hasConceptScore W2533353513C185592680 @default.
- W2533353513 hasConceptScore W2533353513C21951064 @default.
- W2533353513 hasConceptScore W2533353513C2775858608 @default.
- W2533353513 hasConceptScore W2533353513C2777162773 @default.
- W2533353513 hasConceptScore W2533353513C2778186239 @default.
- W2533353513 hasConceptScore W2533353513C41685203 @default.
- W2533353513 hasConceptScore W2533353513C71240020 @default.
- W2533353513 hasConceptScore W2533353513C71924100 @default.
- W2533353513 hasConceptScore W2533353513C86803240 @default.
- W2533353513 hasConceptScore W2533353513C98274493 @default.
- W2533353513 hasIssue "9" @default.
- W2533353513 hasLocation W25333535131 @default.
- W2533353513 hasOpenAccess W2533353513 @default.
- W2533353513 hasPrimaryLocation W25333535131 @default.
- W2533353513 hasRelatedWork W1995372302 @default.
- W2533353513 hasRelatedWork W2049645035 @default.
- W2533353513 hasRelatedWork W2187297522 @default.
- W2533353513 hasRelatedWork W2342962884 @default.
- W2533353513 hasRelatedWork W2587032535 @default.
- W2533353513 hasRelatedWork W2894133534 @default.
- W2533353513 hasRelatedWork W2953158974 @default.
- W2533353513 hasRelatedWork W2972582330 @default.
- W2533353513 hasRelatedWork W3173242815 @default.
- W2533353513 hasRelatedWork W3177839743 @default.
- W2533353513 hasVolume "6" @default.
- W2533353513 isParatext "false" @default.
- W2533353513 isRetracted "false" @default.
- W2533353513 magId "2533353513" @default.
- W2533353513 workType "article" @default.