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- W2533366916 abstract "Improved Indium-111 SPECT imaging should lead to better dose specification in radiotherapy treatment planning; however, photon scatter and down-scatter from the 245- to the 171-keV photopeak represent significant challenges for quantitative SPECT. We have extended to /sup 111/In a general-spectral (GS) scatter-compensation method. List-mode acquisitions of a 1.6-cm-diam. sphere containing /sup 111/In were obtained with the sphere in three different locations on the major axis of a water-filled elliptical cylinder. The sphere was then removed, the phantom was injected with /sup 111/In, repositioned, and scanned repeatedly. High-count, list-mode data from separate sphere and background scans were rebinned into 10-keV windows from 100-280 keV. Attenuated projections, free of scatter and noise, were simulated for use in a least-squares procedure to optimize GS coefficients for a sphere activity-estimation task. Scattered photons in both photopeaks were estimated separately from synthetic noisy projections under different conditions of activity contrast and sphere location; projections were reconstructed with our joint, multi-energy OSEM program. The bias of sphere activity values estimated from projections was less than 7% for both photopeaks and for all contrast values ranging from 2:1 to 8:1; the bias (precision) of sphere activity estimated from OSEM reconstructions was less than 8.5% (3%) for all sphere positions. The GS compensation method is a promising approach for quantitative /sup 111/In SPECT." @default.
- W2533366916 created "2016-10-28" @default.
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- W2533366916 date "2005-08-10" @default.
- W2533366916 modified "2023-09-24" @default.
- W2533366916 title "General-Spectral Method for Improved Quantitative SPECT Imaging of Indium-111" @default.
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- W2533366916 doi "https://doi.org/10.1109/nssmic.2004.1466680" @default.
- W2533366916 hasPublicationYear "2005" @default.
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