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• W2533411571 endingPage "133" @default.
• W2533411571 startingPage "122" @default.
• W2533411571 abstract "Loss of glutamine synthetase (GS) in hippocampal astrocytes has been implicated in the causation of human mesial temporal lobe epilepsy (MTLE). However, the mechanism by which the deficiency in GS leads to epilepsy is incompletely understood. Here we ask how hippocampal GS inhibition affects seizure phenotype and neuronal activation during epilepsy development (epileptogenesis). Epileptogenesis was induced by infusing the irreversible GS blocker methionine sulfoximine (MSO) unilaterally into the hippocampal formation of rats. We then used continuous video-intracranial electroencephalogram (EEG) monitoring and c-Fos immunohistochemistry to determine the type of seizures and spatial distribution of neuronal activation early (1-5days postinfusion) and late (16-43days postinfusion) in epileptogenesis. Early in epileptogenesis, seizures were preferentially mild (stage 1-2), activating neurons in the entorhinal-hippocampal area, the basolateral amygdala, the piriform cortex, the midline thalamus, and the anterior olfactory area. Late in epileptogenesis, the seizures were generally more severe (stages 4-5) with neuronal activation extending to the neocortex, the bed nucleus of the stria terminalis, the mediodorsal thalamus, and the central nucleus of the amygdala. Our findings demonstrate that inhibition of GS focally in the hippocampal formation triggers a process of epileptogenesis characterized by gradual worsening of seizure severity and involvement of progressively larger neuronal populations over a period of several weeks. Knowledge about the underlying mechanism of epileptogenesis is important because such knowledge may result in more specific and efficacious treatments of MTLE by moving away from large and poorly specific surgical resections to highly targeted surgical or pharmacological interventions of the epileptogenic process." @default.
• W2533411571 created "2016-10-28" @default.
• W2533411571 creator A5014608956 @default.
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• W2533411571 creator A5064206652 @default.
• W2533411571 date "2017-02-01" @default.
• W2533411571 modified "2023-10-09" @default.
• W2533411571 title "Progressive neuronal activation accompanies epileptogenesis caused by hippocampal glutamine synthetase inhibition" @default.
• W2533411571 cites W1575705900 @default.
• W2533411571 cites W1629086159 @default.
• W2533411571 cites W1695332227 @default.
• W2533411571 cites W1797972710 @default.
• W2533411571 cites W1856754818 @default.
• W2533411571 cites W19610121 @default.
• W2533411571 cites W1964093752 @default.
• W2533411571 cites W1965953789 @default.
• W2533411571 cites W1967252224 @default.
• W2533411571 cites W1968288733 @default.
• W2533411571 cites W1971293133 @default.
• W2533411571 cites W1971959365 @default.
• W2533411571 cites W1982546760 @default.
• W2533411571 cites W1982933278 @default.
• W2533411571 cites W1995859664 @default.
• W2533411571 cites W1998718544 @default.
• W2533411571 cites W2002608596 @default.
• W2533411571 cites W2002899848 @default.
• W2533411571 cites W2003782689 @default.
• W2533411571 cites W2004305039 @default.
• W2533411571 cites W2007181151 @default.
• W2533411571 cites W2007254199 @default.
• W2533411571 cites W2008955071 @default.
• W2533411571 cites W2011075804 @default.
• W2533411571 cites W2012087299 @default.
• W2533411571 cites W2012496417 @default.
• W2533411571 cites W2014181329 @default.
• W2533411571 cites W2015755811 @default.
• W2533411571 cites W2019884656 @default.
• W2533411571 cites W2021906813 @default.
• W2533411571 cites W2025124682 @default.
• W2533411571 cites W2025389086 @default.
• W2533411571 cites W2031878163 @default.
• W2533411571 cites W2032959779 @default.
• W2533411571 cites W2034336002 @default.
• W2533411571 cites W2041207216 @default.
• W2533411571 cites W2050198572 @default.
• W2533411571 cites W2051064821 @default.
• W2533411571 cites W2052012507 @default.
• W2533411571 cites W2054083058 @default.
• W2533411571 cites W2057470835 @default.
• W2533411571 cites W2065349496 @default.
• W2533411571 cites W2068665404 @default.
• W2533411571 cites W2071650104 @default.
• W2533411571 cites W2072690172 @default.
• W2533411571 cites W2072891357 @default.
• W2533411571 cites W2074878857 @default.
• W2533411571 cites W2081817613 @default.
• W2533411571 cites W2082103350 @default.
• W2533411571 cites W2082598606 @default.
• W2533411571 cites W2083011228 @default.
• W2533411571 cites W2083366727 @default.
• W2533411571 cites W2084133955 @default.
• W2533411571 cites W2085582971 @default.
• W2533411571 cites W2094025655 @default.
• W2533411571 cites W2094930550 @default.
• W2533411571 cites W2095909863 @default.
• W2533411571 cites W2098553579 @default.
• W2533411571 cites W2099513242 @default.
• W2533411571 cites W2106579385 @default.
• W2533411571 cites W2114093008 @default.
• W2533411571 cites W2116586258 @default.
• W2533411571 cites W2118564947 @default.
• W2533411571 cites W2121124402 @default.
• W2533411571 cites W2122832853 @default.
• W2533411571 cites W2127019545 @default.
• W2533411571 cites W2135200619 @default.
• W2533411571 cites W2135328571 @default.
• W2533411571 cites W2135828278 @default.
• W2533411571 cites W2138730880 @default.
• W2533411571 cites W2140257430 @default.
• W2533411571 cites W2142616018 @default.
• W2533411571 cites W2147326269 @default.
• W2533411571 cites W2154755377 @default.
• W2533411571 cites W2156711983 @default.
• W2533411571 cites W2157231487 @default.
• W2533411571 cites W2158294440 @default.
• W2533411571 cites W2159496596 @default.
• W2533411571 cites W2159574392 @default.
• W2533411571 cites W2163328669 @default.
• W2533411571 cites W2167181852 @default.
• W2533411571 cites W2598441763 @default.
• W2533411571 cites W4210979710 @default.
• W2533411571 doi "https://doi.org/10.1016/j.expneurol.2016.10.007" @default.
• W2533411571 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5547560" @default.
• W2533411571 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27769717" @default.

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