Matches in SemOpenAlex for { <https://semopenalex.org/work/W2533422282> ?p ?o ?g. }
- W2533422282 endingPage "362" @default.
- W2533422282 startingPage "358" @default.
- W2533422282 abstract "Intestinal inflammation can impair mucosal healing, thereby establishing a vicious cycle leading to chronic inflammatory bowel disease (IBD). However, the signaling networks driving chronic inflammation remain unclear. Here we report that CD4+ T cells isolated from patients with IBD produce high levels of interleukin-22 binding protein (IL-22BP), the endogenous inhibitor of the tissue-protective cytokine IL-22. Using mouse models, we demonstrate that IBD development requires T cell-derived IL-22BP. Lastly, intestinal CD4+ T cells isolated from IBD patients responsive to treatment with antibodies against tumor necrosis factor-α (anti-TNF-α), the most effective known IBD therapy, exhibited reduced amounts of IL-22BP expression but still expressed IL-22. Our findings suggest that anti-TNF-α therapy may act at least in part by suppressing IL-22BP and point toward a more specific potential therapy for IBD." @default.
- W2533422282 created "2016-10-28" @default.
- W2533422282 creator A5001014545 @default.
- W2533422282 creator A5006293710 @default.
- W2533422282 creator A5007276739 @default.
- W2533422282 creator A5014094111 @default.
- W2533422282 creator A5015887490 @default.
- W2533422282 creator A5031012524 @default.
- W2533422282 creator A5031391280 @default.
- W2533422282 creator A5037272617 @default.
- W2533422282 creator A5039983309 @default.
- W2533422282 creator A5043081740 @default.
- W2533422282 creator A5043715050 @default.
- W2533422282 creator A5047923760 @default.
- W2533422282 creator A5048395035 @default.
- W2533422282 creator A5049498042 @default.
- W2533422282 creator A5049914905 @default.
- W2533422282 creator A5049944999 @default.
- W2533422282 creator A5051022437 @default.
- W2533422282 creator A5064443404 @default.
- W2533422282 creator A5067911784 @default.
- W2533422282 creator A5068923677 @default.
- W2533422282 creator A5073029604 @default.
- W2533422282 creator A5074477057 @default.
- W2533422282 creator A5085697970 @default.
- W2533422282 creator A5088078619 @default.
- W2533422282 creator A5091016746 @default.
- W2533422282 date "2016-10-20" @default.
- W2533422282 modified "2023-10-06" @default.
- W2533422282 title "A pathogenic role for T cell–derived IL-22BP in inflammatory bowel disease" @default.
- W2533422282 cites W1228965893 @default.
- W2533422282 cites W1508191015 @default.
- W2533422282 cites W1938903801 @default.
- W2533422282 cites W1964815186 @default.
- W2533422282 cites W2006432900 @default.
- W2533422282 cites W2008751364 @default.
- W2533422282 cites W2029184793 @default.
- W2533422282 cites W2030702612 @default.
- W2533422282 cites W2042149494 @default.
- W2533422282 cites W2047089179 @default.
- W2533422282 cites W2051014917 @default.
- W2533422282 cites W2055912677 @default.
- W2533422282 cites W2058520337 @default.
- W2533422282 cites W2061625478 @default.
- W2533422282 cites W2069571875 @default.
- W2533422282 cites W2077684186 @default.
- W2533422282 cites W2083610532 @default.
- W2533422282 cites W2084119784 @default.
- W2533422282 cites W2097969181 @default.
- W2533422282 cites W2106464597 @default.
- W2533422282 cites W2114829069 @default.
- W2533422282 cites W2124499950 @default.
- W2533422282 cites W2152882892 @default.
- W2533422282 cites W2153457341 @default.
- W2533422282 cites W2164665293 @default.
- W2533422282 cites W4211241312 @default.
- W2533422282 doi "https://doi.org/10.1126/science.aah5903" @default.
- W2533422282 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27846573" @default.
- W2533422282 hasPublicationYear "2016" @default.
- W2533422282 type Work @default.
- W2533422282 sameAs 2533422282 @default.
- W2533422282 citedByCount "111" @default.
- W2533422282 countsByYear W25334222822017 @default.
- W2533422282 countsByYear W25334222822018 @default.
- W2533422282 countsByYear W25334222822019 @default.
- W2533422282 countsByYear W25334222822020 @default.
- W2533422282 countsByYear W25334222822021 @default.
- W2533422282 countsByYear W25334222822022 @default.
- W2533422282 countsByYear W25334222822023 @default.
- W2533422282 crossrefType "journal-article" @default.
- W2533422282 hasAuthorship W2533422282A5001014545 @default.
- W2533422282 hasAuthorship W2533422282A5006293710 @default.
- W2533422282 hasAuthorship W2533422282A5007276739 @default.
- W2533422282 hasAuthorship W2533422282A5014094111 @default.
- W2533422282 hasAuthorship W2533422282A5015887490 @default.
- W2533422282 hasAuthorship W2533422282A5031012524 @default.
- W2533422282 hasAuthorship W2533422282A5031391280 @default.
- W2533422282 hasAuthorship W2533422282A5037272617 @default.
- W2533422282 hasAuthorship W2533422282A5039983309 @default.
- W2533422282 hasAuthorship W2533422282A5043081740 @default.
- W2533422282 hasAuthorship W2533422282A5043715050 @default.
- W2533422282 hasAuthorship W2533422282A5047923760 @default.
- W2533422282 hasAuthorship W2533422282A5048395035 @default.
- W2533422282 hasAuthorship W2533422282A5049498042 @default.
- W2533422282 hasAuthorship W2533422282A5049914905 @default.
- W2533422282 hasAuthorship W2533422282A5049944999 @default.
- W2533422282 hasAuthorship W2533422282A5051022437 @default.
- W2533422282 hasAuthorship W2533422282A5064443404 @default.
- W2533422282 hasAuthorship W2533422282A5067911784 @default.
- W2533422282 hasAuthorship W2533422282A5068923677 @default.
- W2533422282 hasAuthorship W2533422282A5073029604 @default.
- W2533422282 hasAuthorship W2533422282A5074477057 @default.
- W2533422282 hasAuthorship W2533422282A5085697970 @default.
- W2533422282 hasAuthorship W2533422282A5088078619 @default.
- W2533422282 hasAuthorship W2533422282A5091016746 @default.
- W2533422282 hasConcept C142724271 @default.
- W2533422282 hasConcept C159654299 @default.
- W2533422282 hasConcept C17991360 @default.