Matches in SemOpenAlex for { <https://semopenalex.org/work/W2533437794> ?p ?o ?g. }
- W2533437794 endingPage "22" @default.
- W2533437794 startingPage "13" @default.
- W2533437794 abstract "Two prominent features of tumors that contribute to oncogenic survival signaling are redox disruption, or oxidative stress phenotype, and high autophagy signaling, making both phenomena ideal therapeutic targets. However, the relationship between redox disruption and autophagy signaling is not well characterized and the clinical impact of reactive oxygen species (ROS)-generating chemotherapeutics on autophagy merits immediate attention as autophagy largely contributes to chemotherapeutic resistance. In this commentary we focus on melanoma, using it as an example to provide clarity to current literature regarding the roles of autophagy and redox signaling which can be applicable to initiation and maintenance of most tumor types. Further, we address the crosstalk between ROS and autophagy signaling during pharmacological intervention and cell fate decisions. We attempt to elucidate the role of autophagy in regulating cell fate following treatment with ROS-generating agents in preclinical and clinical settings and discuss the emerging role of autophagy in cell fate decisions and as a cell death mechanism. We also address technical aspects of redox and autophagy evaluation in experimental design and data interpretation. Lastly, we present a provocative view of the clinical relevance, emerging challenges in dual targeting of redox and autophagy pathways for therapy, and the future directions to be addressed in order to advance both basic and translational aspects of this field." @default.
- W2533437794 created "2016-10-28" @default.
- W2533437794 creator A5055705058 @default.
- W2533437794 creator A5076429055 @default.
- W2533437794 date "2017-02-01" @default.
- W2533437794 modified "2023-10-09" @default.
- W2533437794 title "Autophagy: In the cROSshairs of cancer" @default.
- W2533437794 cites W1498612297 @default.
- W2533437794 cites W1523693806 @default.
- W2533437794 cites W1566302744 @default.
- W2533437794 cites W1586712519 @default.
- W2533437794 cites W1591649477 @default.
- W2533437794 cites W1826271789 @default.
- W2533437794 cites W1876742335 @default.
- W2533437794 cites W1890655587 @default.
- W2533437794 cites W1949515053 @default.
- W2533437794 cites W1964377459 @default.
- W2533437794 cites W1964972868 @default.
- W2533437794 cites W1965857762 @default.
- W2533437794 cites W1971915168 @default.
- W2533437794 cites W1973691911 @default.
- W2533437794 cites W1974107986 @default.
- W2533437794 cites W1974702375 @default.
- W2533437794 cites W1981648285 @default.
- W2533437794 cites W1982513324 @default.
- W2533437794 cites W1985087138 @default.
- W2533437794 cites W1987334928 @default.
- W2533437794 cites W1987566410 @default.
- W2533437794 cites W1989051519 @default.
- W2533437794 cites W1991744773 @default.
- W2533437794 cites W1992637754 @default.
- W2533437794 cites W1995080672 @default.
- W2533437794 cites W2001544704 @default.
- W2533437794 cites W2002144764 @default.
- W2533437794 cites W2002226190 @default.
- W2533437794 cites W2005432843 @default.
- W2533437794 cites W2010014306 @default.
- W2533437794 cites W2010656553 @default.
- W2533437794 cites W2017326383 @default.
- W2533437794 cites W2018117610 @default.
- W2533437794 cites W2018845851 @default.
- W2533437794 cites W2020871678 @default.
- W2533437794 cites W2023598683 @default.
- W2533437794 cites W2025971484 @default.
- W2533437794 cites W2029217471 @default.
- W2533437794 cites W2030373903 @default.
- W2533437794 cites W2033843689 @default.
- W2533437794 cites W2034212405 @default.
- W2533437794 cites W2036853407 @default.
- W2533437794 cites W2038595188 @default.
- W2533437794 cites W2039591157 @default.
- W2533437794 cites W2042214600 @default.
- W2533437794 cites W2051642326 @default.
- W2533437794 cites W2052419480 @default.
- W2533437794 cites W2054650618 @default.
- W2533437794 cites W2055510039 @default.
- W2533437794 cites W2059254359 @default.
- W2533437794 cites W2059388879 @default.
- W2533437794 cites W2062466754 @default.
- W2533437794 cites W2065602008 @default.
- W2533437794 cites W2071912398 @default.
- W2533437794 cites W2073015226 @default.
- W2533437794 cites W2075287142 @default.
- W2533437794 cites W2077168519 @default.
- W2533437794 cites W2080689345 @default.
- W2533437794 cites W2082922092 @default.
- W2533437794 cites W2085442981 @default.
- W2533437794 cites W2091847864 @default.
- W2533437794 cites W2095761326 @default.
- W2533437794 cites W2096433384 @default.
- W2533437794 cites W2096575630 @default.
- W2533437794 cites W2096584578 @default.
- W2533437794 cites W2103147617 @default.
- W2533437794 cites W2103667120 @default.
- W2533437794 cites W2103701382 @default.
- W2533437794 cites W2109500685 @default.
- W2533437794 cites W2114806766 @default.
- W2533437794 cites W2118959823 @default.
- W2533437794 cites W2123073351 @default.
- W2533437794 cites W2124863040 @default.
- W2533437794 cites W2126937565 @default.
- W2533437794 cites W2127120957 @default.
- W2533437794 cites W2127364075 @default.
- W2533437794 cites W2127625280 @default.
- W2533437794 cites W2133304718 @default.
- W2533437794 cites W2136147886 @default.
- W2533437794 cites W2137831623 @default.
- W2533437794 cites W2139830524 @default.
- W2533437794 cites W2140464899 @default.
- W2533437794 cites W2141323200 @default.
- W2533437794 cites W2142043975 @default.
- W2533437794 cites W2154265087 @default.
- W2533437794 cites W2157002874 @default.
- W2533437794 cites W2157371923 @default.
- W2533437794 cites W2159334325 @default.
- W2533437794 cites W2160411684 @default.
- W2533437794 cites W2163341926 @default.
- W2533437794 cites W2168705167 @default.