FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2533510557> ?p ?o ?g. }

• W2533510557 endingPage "865" @default.
• W2533510557 startingPage "861" @default.
• W2533510557 abstract "Endophytes have the potential to synthesize various bioactive secondary metabolites. The aim of the study was to find new cytotoxic and antibacterial metabolites from endophytic fungus, Cladosporium sp. isolated from the leaves of Rauwolfia serpentina (L.) Benth. ex Kurz. (Fam: Apocyanaceae).The endophytic fungus was grown on potato dextrose agar medium and extracted using ethyl acetate. Secondary metabolites were isolated by chromatographic separation and re-crystallization, and structures were confirmed by 1H NMR, 13C NMR and mass spectroscopic data. The cytotoxicity was determined by WST-1 assay and brine shrimp lethality bioassay, while antibacterial activity was assessed by disc diffusion method.Two naphthoquinones, namely anhydrofusarubin (1) and methyl ether of fusarubin (2), were isolated from Cladosporium sp. The isolated compounds 1 and 2, by WST-1 assay against human leukemia cells (K-562) showed potential cytotoxicity with IC50 values of 3.97 μg/mL and 3.58 μg/mL, respectively. Initial screening of crude ethyl acetate extract and column fractions F-8 and F-10 exhibited noticeable cytotoxicity to brine shimp nauplii with LC50 values of 42.8, 1.2 and 2.1 μg/mL, respectively. Moreover, the isolated compound 2 (40 μg/disc) showed prominent activities against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Bacillus megaterium with an average zone of inhibition of 27 mm, 25 mm, 24 mm and 22 mm, respectively and the activities were compared with kanamycin (30 μg/disc).Our findings indicate that anhydrofusarubin (1) and methyl ether of fusarubin (2) might be useful lead compounds to develop potential cytotoxic and antimicrobial drugs." @default.
• W2533510557 created "2016-10-28" @default.
• W2533510557 creator A5033990408 @default.
• W2533510557 creator A5048054761 @default.
• W2533510557 creator A5052812213 @default.
• W2533510557 creator A5061432196 @default.
• W2533510557 creator A5076419700 @default.
• W2533510557 creator A5089812599 @default.
• W2533510557 date "2016-01-01" @default.
• W2533510557 modified "2023-10-01" @default.
• W2533510557 title "Cytotoxic and antibacterial naphthoquinones from an endophytic fungus, Cladosporium sp." @default.
• W2533510557 cites W1837518786 @default.
• W2533510557 cites W1965087628 @default.
• W2533510557 cites W1966832052 @default.
• W2533510557 cites W1971309376 @default.
• W2533510557 cites W1978942689 @default.
• W2533510557 cites W1981196495 @default.
• W2533510557 cites W1992446742 @default.
• W2533510557 cites W1995635215 @default.
• W2533510557 cites W2003160601 @default.
• W2533510557 cites W2003226432 @default.
• W2533510557 cites W2003597028 @default.
• W2533510557 cites W2020219147 @default.
• W2533510557 cites W2023091176 @default.
• W2533510557 cites W2027118285 @default.
• W2533510557 cites W2045265255 @default.
• W2533510557 cites W2050010765 @default.
• W2533510557 cites W2053063880 @default.
• W2533510557 cites W2053481791 @default.
• W2533510557 cites W2054591299 @default.
• W2533510557 cites W2067661859 @default.
• W2533510557 cites W2073265813 @default.
• W2533510557 cites W2074509460 @default.
• W2533510557 cites W2075843047 @default.
• W2533510557 cites W2084298114 @default.
• W2533510557 cites W2093346207 @default.
• W2533510557 cites W2136931384 @default.
• W2533510557 cites W2145679005 @default.
• W2533510557 cites W2168844825 @default.
• W2533510557 cites W2203506194 @default.
• W2533510557 cites W2206165528 @default.
• W2533510557 cites W2315722303 @default.
• W2533510557 cites W2461191826 @default.
• W2533510557 doi "https://doi.org/10.1016/j.toxrep.2016.10.005" @default.
• W2533510557 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5616083" @default.
• W2533510557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28959613" @default.
• W2533510557 hasPublicationYear "2016" @default.
• W2533510557 type Work @default.
• W2533510557 sameAs 2533510557 @default.
• W2533510557 citedByCount "42" @default.
• W2533510557 countsByYear W25335105572017 @default.
• W2533510557 countsByYear W25335105572018 @default.
• W2533510557 countsByYear W25335105572019 @default.
• W2533510557 countsByYear W25335105572020 @default.
• W2533510557 countsByYear W25335105572021 @default.
• W2533510557 countsByYear W25335105572022 @default.
• W2533510557 countsByYear W25335105572023 @default.
• W2533510557 crossrefType "journal-article" @default.
• W2533510557 hasAuthorship W2533510557A5033990408 @default.
• W2533510557 hasAuthorship W2533510557A5048054761 @default.
• W2533510557 hasAuthorship W2533510557A5052812213 @default.
• W2533510557 hasAuthorship W2533510557A5061432196 @default.
• W2533510557 hasAuthorship W2533510557A5076419700 @default.
• W2533510557 hasAuthorship W2533510557A5089812599 @default.
• W2533510557 hasBestOaLocation W25335105571 @default.
• W2533510557 hasConcept C109316439 @default.
• W2533510557 hasConcept C185592680 @default.
• W2533510557 hasConcept C18903297 @default.
• W2533510557 hasConcept C202751555 @default.
• W2533510557 hasConcept C2775873308 @default.
• W2533510557 hasConcept C2777484150 @default.
• W2533510557 hasConcept C2779756257 @default.
• W2533510557 hasConcept C2779858419 @default.
• W2533510557 hasConcept C2780104969 @default.
• W2533510557 hasConcept C2780989563 @default.
• W2533510557 hasConcept C31903555 @default.
• W2533510557 hasConcept C43617362 @default.
• W2533510557 hasConcept C523546767 @default.
• W2533510557 hasConcept C54355233 @default.
• W2533510557 hasConcept C55493867 @default.
• W2533510557 hasConcept C59822182 @default.
• W2533510557 hasConcept C86803240 @default.
• W2533510557 hasConcept C89423630 @default.
• W2533510557 hasConcept C89638049 @default.
• W2533510557 hasConceptScore W2533510557C109316439 @default.
• W2533510557 hasConceptScore W2533510557C185592680 @default.
• W2533510557 hasConceptScore W2533510557C18903297 @default.
• W2533510557 hasConceptScore W2533510557C202751555 @default.
• W2533510557 hasConceptScore W2533510557C2775873308 @default.
• W2533510557 hasConceptScore W2533510557C2777484150 @default.
• W2533510557 hasConceptScore W2533510557C2779756257 @default.
• W2533510557 hasConceptScore W2533510557C2779858419 @default.
• W2533510557 hasConceptScore W2533510557C2780104969 @default.
• W2533510557 hasConceptScore W2533510557C2780989563 @default.
• W2533510557 hasConceptScore W2533510557C31903555 @default.
• W2533510557 hasConceptScore W2533510557C43617362 @default.
• W2533510557 hasConceptScore W2533510557C523546767 @default.
• W2533510557 hasConceptScore W2533510557C54355233 @default.

• next