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- W2533517231 abstract "Nicotinic acetylcholine receptors (nAChRs) produce widespread and complex effects on neocortex excitability. We studied how heteromeric nAChRs regulate inhibitory post-synaptic currents (IPSCs), in fast-spiking (FS) layer V neurons of the mouse frontal area 2 (Fr2). In the presence of blockers of ionotropic glutamate receptors, tonic application of 10μM nicotine augmented the spontaneous IPSC frequency, with minor alterations of amplitudes and kinetics. These effects were studied since the 3rd postnatal week, and persisted throughout the first two months of postnatal life. The action of nicotine was blocked by 1μM dihydro-β-erythroidine (DHβE; specific for α4∗ nAChRs), but not 10nM methyllycaconitine (MLA; specific for α7∗ nAChRs). It was mimicked by 10nM 5-iodo-3-[2(S)-azetidinylmethoxy]pyridine (5-IA; which activates β2∗ nAChRs). Similar results were obtained on miniature IPSCs (mIPSCs). Moreover, during the first five postnatal weeks, approximately 50% of FS cells displayed DHβE-sensitive whole-cell nicotinic currents. This percentage decreased to ∼5% in mice older than P45. By confocal microscopy, the α4 nAChR subunit was immunocytochemically identified on interneurons expressing either parvalbumin (PV), which mainly labels FS cells, or somatostatin (SOM), which labels the other major interneuron population in layer V. GABAergic terminals expressing α4 were observed to be juxtaposed to PV-positive (PV+) cells. A fraction of these terminals displayed PV immunoreactivity. We conclude that α4β2∗ nAChRs can produce sustained regulation of FS cells in Fr2 layer V. The effect presents a presynaptic component, whereas the somatic regulation decreases with age. These mechanisms may contribute to the nAChR-dependent stimulation of excitability during cognitive tasks as well as to the hyperexcitability caused by hyperfunctional heteromeric nAChRs in sleep-related epilepsy." @default.
- W2533517231 created "2016-10-28" @default.
- W2533517231 creator A5006988500 @default.
- W2533517231 creator A5008203817 @default.
- W2533517231 creator A5025289089 @default.
- W2533517231 creator A5031169399 @default.
- W2533517231 creator A5081077834 @default.
- W2533517231 date "2017-01-01" @default.
- W2533517231 modified "2023-09-29" @default.
- W2533517231 title "α4β2 ∗ nicotinic receptors stimulate GABA release onto fast-spiking cells in layer V of mouse prefrontal (Fr2) cortex" @default.
- W2533517231 cites W1481081425 @default.
- W2533517231 cites W1570361834 @default.
- W2533517231 cites W1836832549 @default.
- W2533517231 cites W1840472544 @default.
- W2533517231 cites W1923448222 @default.
- W2533517231 cites W1929306675 @default.
- W2533517231 cites W1934489743 @default.
- W2533517231 cites W1939947624 @default.
- W2533517231 cites W1970719523 @default.
- W2533517231 cites W1970789949 @default.
- W2533517231 cites W1977500396 @default.
- W2533517231 cites W1983423336 @default.
- W2533517231 cites W1984054433 @default.
- W2533517231 cites W1985733673 @default.
- W2533517231 cites W1992424371 @default.
- W2533517231 cites W1992910467 @default.
- W2533517231 cites W1995721971 @default.
- W2533517231 cites W1997210267 @default.
- W2533517231 cites W1997953085 @default.
- W2533517231 cites W2002108201 @default.
- W2533517231 cites W2002148330 @default.
- W2533517231 cites W2002168442 @default.
- W2533517231 cites W2005416599 @default.
- W2533517231 cites W2009833394 @default.
- W2533517231 cites W2010065714 @default.
- W2533517231 cites W2012174837 @default.
- W2533517231 cites W2015061703 @default.
- W2533517231 cites W2019159182 @default.
- W2533517231 cites W2021755555 @default.
- W2533517231 cites W2022503151 @default.
- W2533517231 cites W2022982192 @default.
- W2533517231 cites W2027661077 @default.
- W2533517231 cites W2031034568 @default.
- W2533517231 cites W2031142338 @default.
- W2533517231 cites W2035946761 @default.
- W2533517231 cites W2047250466 @default.
- W2533517231 cites W2047347093 @default.
- W2533517231 cites W2056661320 @default.
- W2533517231 cites W2057551724 @default.
- W2533517231 cites W2057787317 @default.
- W2533517231 cites W2059234084 @default.
- W2533517231 cites W2060052368 @default.
- W2533517231 cites W2061901670 @default.
- W2533517231 cites W2062624347 @default.
- W2533517231 cites W2064025488 @default.
- W2533517231 cites W2064447463 @default.
- W2533517231 cites W2064978509 @default.
- W2533517231 cites W2070264536 @default.
- W2533517231 cites W2070295245 @default.
- W2533517231 cites W2075847995 @default.
- W2533517231 cites W2077516679 @default.
- W2533517231 cites W2079150153 @default.
- W2533517231 cites W2080285028 @default.
- W2533517231 cites W2086069938 @default.
- W2533517231 cites W2087301801 @default.
- W2533517231 cites W2089242029 @default.
- W2533517231 cites W2089823661 @default.
- W2533517231 cites W2095536623 @default.
- W2533517231 cites W2095792916 @default.
- W2533517231 cites W2098098632 @default.
- W2533517231 cites W2102293491 @default.
- W2533517231 cites W2102503807 @default.
- W2533517231 cites W2104838343 @default.
- W2533517231 cites W2104849082 @default.
- W2533517231 cites W2108773062 @default.
- W2533517231 cites W2109825396 @default.
- W2533517231 cites W2113064032 @default.
- W2533517231 cites W2115750269 @default.
- W2533517231 cites W2116846032 @default.
- W2533517231 cites W2117190512 @default.
- W2533517231 cites W2124733101 @default.
- W2533517231 cites W2130432173 @default.
- W2533517231 cites W2131797361 @default.
- W2533517231 cites W2135895844 @default.
- W2533517231 cites W2136585162 @default.
- W2533517231 cites W2137983860 @default.
- W2533517231 cites W2139250347 @default.
- W2533517231 cites W2139842218 @default.
- W2533517231 cites W2147122561 @default.
- W2533517231 cites W2147617498 @default.
- W2533517231 cites W2149561999 @default.
- W2533517231 cites W2151675314 @default.
- W2533517231 cites W2159656068 @default.
- W2533517231 cites W2162081584 @default.
- W2533517231 cites W2165896003 @default.
- W2533517231 cites W2171614525 @default.
- W2533517231 cites W2442679071 @default.
- W2533517231 cites W4295813505 @default.