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- W2533702022 abstract "Glucocorticoids are steroids that reduce inflammation and are used as immunosuppressive drugs for many diseases. They are also the mainstay for the treatment of minimal change nephropathy (MCN), which is characterised by an absence of inflammation. Their mechanisms of action remain elusive. Evidence suggests that immunomodulatory drugs can directly act on glomerular epithelial cells or 'podocytes', the cell type which is the main target of injury in MCN. To understand the nature of glucocorticoid effects on non-immune cell functions, we generated RNA sequencing data from human podocyte cell lines and identified the genes that are significantly regulated in dexamethasone-treated podocytes compared to vehicle-treated cells. The upregulated genes are of functional relevance to cytoskeleton-related processes, whereas the downregulated genes mostly encode pro-inflammatory cytokines and growth factors. We observed a tendency for dexamethasone-upregulated genes to be downregulated in MCN patients. Integrative analysis revealed gene networks composed of critical signaling pathways that are likely targeted by dexamethasone in podocytes." @default.
- W2533702022 created "2016-10-28" @default.
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- W2533702022 date "2016-10-24" @default.
- W2533702022 modified "2023-10-01" @default.
- W2533702022 title "RNA sequencing analysis of human podocytes reveals glucocorticoid regulated gene networks targeting non-immune pathways" @default.
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- W2533702022 doi "https://doi.org/10.1038/srep35671" @default.
- W2533702022 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5075905" @default.
- W2533702022 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27774996" @default.
- W2533702022 hasPublicationYear "2016" @default.
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