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• W2533716009 abstract "Abstract A UPLC-PDA-QTOFMS-guided isolation strategy was employed to screen and track potentially new compounds from Garcinia oblongifolia . As a result, two new prenylated xanthones, oblongixanthones D and E ( 1 – 2 ), six new prenylated benzoylphloroglucinol derivatives, oblongifolins V–Z ( 3 – 7 ) and oblongifolin AA ( 8 ), as well as a known compound oblongifolin L ( 9 ), were isolated from the EtOAc-soluble fraction of an acetone extract of the leaves of Garcinia oblongifolia guided by UPLC-PDA-QTOFMS analysis. The structures of the new compounds were elucidated by 1D- and 2D-NMR spectroscopic analysis and mass spectrometry. Experimental and calculated ECD spectra were used to determine the absolute configurations. The results of wound healing and transwell migration assay showed that oblongixanthones D ( 1 ), E ( 2 ), and oblongifolin L ( 9 ) have the ability to inhibit cancer cell migration in lower cytotoxic concentrations. Western blotting results showed that these compounds exhibited an anti-metastasis effect mainly through downregulating RAF protein levels. In addition, 2 and 9 could inhibit phospho-MEK and phospho-ERK at downstream. Moreover, 1 , 2 , and 9 could inhibit snail protein level, suggesting that they could regulate the EMT pathway." @default.
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• W2533716009 date "2016-10-21" @default.
• W2533716009 modified "2023-09-27" @default.
• W2533716009 title "UPLC-PDA-QTOFMS-guided isolation of prenylated xanthones and benzoylphloroglucinols from the leaves of Garcinia oblongifolia and their migration-inhibitory activity" @default.
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• W2533716009 doi "https://doi.org/10.1038/srep35789" @default.
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