Matches in SemOpenAlex for { <https://semopenalex.org/work/W2533719900> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W2533719900 abstract "Performance and change in polygenic neurocognitive phenotypes during non-demented aging may be predicted and modified through selective interactions among genetic risk indices compiled with polymorphisms associated with both Alzheimer’s disease (AD) and typical brain aging. Suggestive evidence indicates that a cumulative Cognitive Aging Genetic Risk Score [CA-GRS; Catechol-O-methyltransferase (COMT, risk=Val+) + Brain-derived neurotrophic factor (BDNF, risk=Met+)] predicts executive function (EF) performance but the effect may be modified by the leading AD genetic risk, Apolipoprotein E (APOE). Given the dynamic and inter-related mechanisms underlying transitions from non-demented aging to dementia, we examined three-way interactions among three genetic risk clusters: (1) APOE (risk=ε4+), (2) CA-GRS, and (3) a new AD Genetic Risk Score [AD-GRS; Clusterin (CLU, risk=C+) + Complement receptor 1 (CR1, risk=A+) + Phosphatidylinositol-binding clathrin assembly protein (PICALM, risk=T+)] in predicting EF performance and change. We used a three-wave (∼9-year) longitudinal sample of non-demented older adults (baseline N=634; range=53-95 years; Mage=70.6) from the Victoria Longitudinal Study. We tested (1) the CA-GRS effect on EF, (2) moderation by AD-GRS on the CA-GRS model, and (3) these models as stratified by APOE. Targeted follow-up analyses were conducted to inform mechanism interpretations. We used confirmatory factor analysis (EF latent variable), latent growth curve modeling, and path analysis. First, APOE modified the CA-GRS effect on EF in that higher genetic risk was associated with lower performance but only among APOE ε4+ carriers (β=-0.307; p=.013). Second, AD-GRS moderated the CA-GRS effect on EF as stratified by APOE. Specifically, only APOE ε4+ carriers with higher CA-GRS and higher AD-GRS risk had lower EF performance at the centering age (75 years) (β=-0.297; p=.021) and borderline 9-year decline (β=-0.011; p=.079). Third, in contrast, no moderation effect was observed for either (1) APOE ε4+ carriers with lower AD-GRS risk or (2) APOE non-risk carriers. In non-demented older adults, genetic risk from both common cognitive aging and AD-related indices may interact in intensification networks to differentially predict (1) level and trajectories of cognitive change and (2) potential vulnerability for transitions into dementia. Multivariate longitudinal research can aid in the detection of potential mechanisms underlying early differential changes." @default.
- W2533719900 created "2016-10-28" @default.
- W2533719900 creator A5057288205 @default.
- W2533719900 creator A5067045341 @default.
- W2533719900 date "2016-07-01" @default.
- W2533719900 modified "2023-09-27" @default.
- W2533719900 title "P4-051: A Network of Genetic Effects on Non-Demented Cognitive Aging: Alzheimer's Genetic Risk (CLU + CR1 + PICALM ) Intensifies Cognitive Aging Genetic Risk (COMT + BDNF ) Selectively for APOE E4+ Carriers" @default.
- W2533719900 doi "https://doi.org/10.1016/j.jalz.2016.06.2141" @default.
- W2533719900 hasPublicationYear "2016" @default.
- W2533719900 type Work @default.
- W2533719900 sameAs 2533719900 @default.
- W2533719900 citedByCount "1" @default.
- W2533719900 countsByYear W25337199002021 @default.
- W2533719900 crossrefType "journal-article" @default.
- W2533719900 hasAuthorship W2533719900A5057288205 @default.
- W2533719900 hasAuthorship W2533719900A5067045341 @default.
- W2533719900 hasConcept C104317684 @default.
- W2533719900 hasConcept C106208931 @default.
- W2533719900 hasConcept C126322002 @default.
- W2533719900 hasConcept C135763542 @default.
- W2533719900 hasConcept C143998085 @default.
- W2533719900 hasConcept C153209595 @default.
- W2533719900 hasConcept C15744967 @default.
- W2533719900 hasConcept C169760540 @default.
- W2533719900 hasConcept C169900460 @default.
- W2533719900 hasConcept C172467417 @default.
- W2533719900 hasConcept C190283241 @default.
- W2533719900 hasConcept C2779134260 @default.
- W2533719900 hasConcept C2779476363 @default.
- W2533719900 hasConcept C54355233 @default.
- W2533719900 hasConcept C57089818 @default.
- W2533719900 hasConcept C71924100 @default.
- W2533719900 hasConcept C86803240 @default.
- W2533719900 hasConceptScore W2533719900C104317684 @default.
- W2533719900 hasConceptScore W2533719900C106208931 @default.
- W2533719900 hasConceptScore W2533719900C126322002 @default.
- W2533719900 hasConceptScore W2533719900C135763542 @default.
- W2533719900 hasConceptScore W2533719900C143998085 @default.
- W2533719900 hasConceptScore W2533719900C153209595 @default.
- W2533719900 hasConceptScore W2533719900C15744967 @default.
- W2533719900 hasConceptScore W2533719900C169760540 @default.
- W2533719900 hasConceptScore W2533719900C169900460 @default.
- W2533719900 hasConceptScore W2533719900C172467417 @default.
- W2533719900 hasConceptScore W2533719900C190283241 @default.
- W2533719900 hasConceptScore W2533719900C2779134260 @default.
- W2533719900 hasConceptScore W2533719900C2779476363 @default.
- W2533719900 hasConceptScore W2533719900C54355233 @default.
- W2533719900 hasConceptScore W2533719900C57089818 @default.
- W2533719900 hasConceptScore W2533719900C71924100 @default.
- W2533719900 hasConceptScore W2533719900C86803240 @default.
- W2533719900 hasIssue "7S_Part_21" @default.
- W2533719900 hasLocation W25337199001 @default.
- W2533719900 hasOpenAccess W2533719900 @default.
- W2533719900 hasPrimaryLocation W25337199001 @default.
- W2533719900 hasRelatedWork W1966874118 @default.
- W2533719900 hasRelatedWork W1971866805 @default.
- W2533719900 hasRelatedWork W2069459264 @default.
- W2533719900 hasRelatedWork W2070716601 @default.
- W2533719900 hasRelatedWork W2085843402 @default.
- W2533719900 hasRelatedWork W2119182614 @default.
- W2533719900 hasRelatedWork W2748952813 @default.
- W2533719900 hasRelatedWork W2899084033 @default.
- W2533719900 hasRelatedWork W2919338961 @default.
- W2533719900 hasRelatedWork W4281655237 @default.
- W2533719900 hasVolume "12" @default.
- W2533719900 isParatext "false" @default.
- W2533719900 isRetracted "false" @default.
- W2533719900 magId "2533719900" @default.
- W2533719900 workType "article" @default.