FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2533747939> ?p ?o ?g. }

• W2533747939 abstract "A self-consistent field study is presented on the design of active and passive targeting block-copolymeric micelles. These micelles form in water by self-assembly of triblock copolymers with a hydrophilic middle block and two hydrophobic outer blocks. A minority amount of diblock copolymers with the same chemistry is taken to coassemble into these micelles. At the end of the hydrophilic block of the diblock copolymers, a targeting moiety (TM) is present. Assuming that the rotation of the micelle towards the target is sufficiently fast, we can elaborate a single gradient cell model, wherein the micelle is in the center and the receptor (R) substrate exists on the outer plane of the spherical coordinate system. The distribution function of the targeting moiety corresponds to a Landau free energy with local minima and corresponding maxima. The lowest minimum, which is the ground state, shifts from within the micelle to the adsorbing state upon bringing the substrate closer to the micelle, implying a jumplike translocation of the targeting moiety. Equally deep minima represent the binodal of the phase transition, which is, due to the finite chain length, first-order like. The maximum in-between the two relevant minima implies that there is an activation barrier for the targeting moiety to reach the receptor surface. We localize the parameter space wherein the targeting moiety is (when the micelle is far from the target) preferably hidden in the stealthy hydrophilic corona of the micelle, which is desirable to avoid undesired immune responses, and still can jump out of the corona to reach the target quick enough, that is, when the barrier height is sufficiently low. The latter requirement may be identified by a spinodal condition. We found that such hidden TMs can still establish a TM-R contact at distances up to twice the corona size. The translocation transition will work best when the affinity of the TM for the core is avoided and when hydrophilic TMs are selected." @default.
• W2533747939 created "2016-10-28" @default.
• W2533747939 creator A5032301141 @default.
• W2533747939 creator A5047129609 @default.
• W2533747939 creator A5068090088 @default.
• W2533747939 creator A5075112861 @default.
• W2533747939 date "2016-10-21" @default.
• W2533747939 modified "2023-10-17" @default.
• W2533747939 title "Design of block-copolymer-based micelles for active and passive targeting" @default.
• W2533747939 cites W1968534837 @default.
• W2533747939 cites W1973186951 @default.
• W2533747939 cites W1977388087 @default.
• W2533747939 cites W1983533483 @default.
• W2533747939 cites W1984195944 @default.
• W2533747939 cites W1990455420 @default.
• W2533747939 cites W1996998905 @default.
• W2533747939 cites W2000750191 @default.
• W2533747939 cites W2002516695 @default.
• W2533747939 cites W2014537537 @default.
• W2533747939 cites W2014680165 @default.
• W2533747939 cites W2026680301 @default.
• W2533747939 cites W2030005642 @default.
• W2533747939 cites W2043179269 @default.
• W2533747939 cites W2046851174 @default.
• W2533747939 cites W2052933267 @default.
• W2533747939 cites W2057632167 @default.
• W2533747939 cites W2068491059 @default.
• W2533747939 cites W2072750787 @default.
• W2533747939 cites W2074049796 @default.
• W2533747939 cites W2084968676 @default.
• W2533747939 cites W2086510008 @default.
• W2533747939 cites W2087020662 @default.
• W2533747939 cites W2089773350 @default.
• W2533747939 cites W2091500503 @default.
• W2533747939 cites W2101312385 @default.
• W2533747939 cites W2105497755 @default.
• W2533747939 cites W2119016522 @default.
• W2533747939 cites W2127410754 @default.
• W2533747939 cites W2132218003 @default.
• W2533747939 cites W2143650299 @default.
• W2533747939 cites W2164841185 @default.
• W2533747939 cites W2313899111 @default.
• W2533747939 cites W2487240357 @default.
• W2533747939 cites W2945930932 @default.
• W2533747939 doi "https://doi.org/10.1103/physreve.94.042503" @default.
• W2533747939 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27841591" @default.
• W2533747939 hasPublicationYear "2016" @default.
• W2533747939 type Work @default.
• W2533747939 sameAs 2533747939 @default.
• W2533747939 citedByCount "4" @default.
• W2533747939 countsByYear W25337479392017 @default.
• W2533747939 countsByYear W25337479392020 @default.
• W2533747939 countsByYear W25337479392021 @default.
• W2533747939 crossrefType "journal-article" @default.
• W2533747939 hasAuthorship W2533747939A5032301141 @default.
• W2533747939 hasAuthorship W2533747939A5047129609 @default.
• W2533747939 hasAuthorship W2533747939A5068090088 @default.
• W2533747939 hasAuthorship W2533747939A5075112861 @default.
• W2533747939 hasBestOaLocation W25337479392 @default.
• W2533747939 hasConcept C11268172 @default.
• W2533747939 hasConcept C134306372 @default.
• W2533747939 hasConcept C15920480 @default.
• W2533747939 hasConcept C159467904 @default.
• W2533747939 hasConcept C159985019 @default.
• W2533747939 hasConcept C178790620 @default.
• W2533747939 hasConcept C184651966 @default.
• W2533747939 hasConcept C185592680 @default.
• W2533747939 hasConcept C186633575 @default.
• W2533747939 hasConcept C192562407 @default.
• W2533747939 hasConcept C2776568683 @default.
• W2533747939 hasConcept C33923547 @default.
• W2533747939 hasConcept C521977710 @default.
• W2533747939 hasConcept C71240020 @default.
• W2533747939 hasConceptScore W2533747939C11268172 @default.
• W2533747939 hasConceptScore W2533747939C134306372 @default.
• W2533747939 hasConceptScore W2533747939C15920480 @default.
• W2533747939 hasConceptScore W2533747939C159467904 @default.
• W2533747939 hasConceptScore W2533747939C159985019 @default.
• W2533747939 hasConceptScore W2533747939C178790620 @default.
• W2533747939 hasConceptScore W2533747939C184651966 @default.
• W2533747939 hasConceptScore W2533747939C185592680 @default.
• W2533747939 hasConceptScore W2533747939C186633575 @default.
• W2533747939 hasConceptScore W2533747939C192562407 @default.
• W2533747939 hasConceptScore W2533747939C2776568683 @default.
• W2533747939 hasConceptScore W2533747939C33923547 @default.
• W2533747939 hasConceptScore W2533747939C521977710 @default.
• W2533747939 hasConceptScore W2533747939C71240020 @default.
• W2533747939 hasIssue "4" @default.
• W2533747939 hasLocation W25337479391 @default.
• W2533747939 hasLocation W25337479392 @default.
• W2533747939 hasLocation W25337479393 @default.
• W2533747939 hasLocation W25337479394 @default.
• W2533747939 hasOpenAccess W2533747939 @default.
• W2533747939 hasPrimaryLocation W25337479391 @default.
• W2533747939 hasRelatedWork W1694025646 @default.
• W2533747939 hasRelatedWork W194725506 @default.
• W2533747939 hasRelatedWork W2039240171 @default.
• W2533747939 hasRelatedWork W2055023314 @default.
• W2533747939 hasRelatedWork W2061975134 @default.
• W2533747939 hasRelatedWork W2092822275 @default.

• next