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• W2533780334 abstract "Central dopaminergic neurons play an important role in motor, emotional, and cog­ nitive behavior. These dopaminergic systems are affected both by normal aging and by various diseases. The most prominent of these diseases is Parkinson's disease, which is associated with a gradual and progressive loss of dopaminergic neurons in the human brain. Studies on human brain have revealed a remarkable ability of these neurons to compensate for partial destruction of their systems, and these findings have prompted numerous investigations of the adaptive changes of dopaminergic neurons to experimental injury. The findings reveal that dopaminergic neurons react to a partial lesion of their pathways with several adaptive changes. Dopaminergic neurons surviving a partial lesion respond by increasing transmitter synthesis and release. Furthermore, after near-total lesions, a supersensitivity of postsynaptic transmitter receptors develops. Because of these bio­ chemical adaptive changes, few surviving neurons are able to compensate for the loss of a majority of other dopaminergic neurons. Recent findings indicate that biochemical adaptive processes can be further stimulated by pharmacological manipulation. The possible mechanisms of actions of these pharmacological agents are discussed." @default.
• W2533780334 created "2016-10-28" @default.
• W2533780334 creator A5054270816 @default.
• W2533780334 creator A5074151067 @default.
• W2533780334 date "1988-01-01" @default.
• W2533780334 modified "2023-09-24" @default.
• W2533780334 title "ADAPTIVE CHANGES IN CENTRAL DOPAMINERGIC NEURONS AFTER INJURY EFFECTS OF DRUGS" @default.
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• W2533780334 hasPublicationYear "1988" @default.
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