FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2534103601> ?p ?o ?g. }

• W2534103601 abstract "Abstract Circulating long non-coding RNAs (lncRNAs) serve as valuable biomarkers in a number of human diseases. However, lncRNA biomarkers have yet to be identified in obesity. We aim to characterize circulating lncRNA expression in obese and non-obese human subjects. First, we assessed the genome-wide circulating lncRNA expression profiles in blood from 3 obese and 3 non-obese human subjects. We found a significant decrease in circulating levels of three lncRNAs (lncRNA-p5549, lncRNA-p21015 and lncRNA-p19461) in obese human subjects only. Next, using RT-PCR we measured the expression levels of these three lncRNAs in 33 obese and 33 non-obese human subjects and found similar differences. Moreover, we found a negative correlation between circulating levels of these three lncRNAs and body mass index (BMI), waist circumference, waist to hip ratio and fasting insulin. There was also a significant negative correlation between expression of lncRNA-p19461 and homeostasis model assessment-estimated insulin resistance. Finally, we tested the circulating levels of these three lncRNAs in 8 obese human subjects after a 12-week diet-induced weight loss program. We found that only lncRNA-p19461 expression level significantly increased. In summary, circulating lncRNAs are deregulated in obesity. Weight loss–induced changes in this profile support this observation and suggest a potential mechanistic relevance." @default.
• W2534103601 created "2016-10-28" @default.
• W2534103601 creator A5000613011 @default.
• W2534103601 creator A5018898066 @default.
• W2534103601 creator A5026672460 @default.
• W2534103601 creator A5038880076 @default.
• W2534103601 creator A5058502781 @default.
• W2534103601 creator A5079052592 @default.
• W2534103601 creator A5087404353 @default.
• W2534103601 creator A5091733618 @default.
• W2534103601 date "2016-10-21" @default.
• W2534103601 modified "2023-10-16" @default.
• W2534103601 title "Differentially expressed circulating LncRNAs and mRNA identified by microarray analysis in obese patients" @default.
• W2534103601 cites W1508825525 @default.
• W2534103601 cites W1537007105 @default.
• W2534103601 cites W1716301446 @default.
• W2534103601 cites W1762688284 @default.
• W2534103601 cites W1910886072 @default.
• W2534103601 cites W1946661286 @default.
• W2534103601 cites W1964634240 @default.
• W2534103601 cites W1974892271 @default.
• W2534103601 cites W1985359974 @default.
• W2534103601 cites W1985789209 @default.
• W2534103601 cites W1999746344 @default.
• W2534103601 cites W2008833309 @default.
• W2534103601 cites W2034810986 @default.
• W2534103601 cites W2039434363 @default.
• W2534103601 cites W2061712483 @default.
• W2534103601 cites W2065168857 @default.
• W2534103601 cites W2068494256 @default.
• W2534103601 cites W2071271349 @default.
• W2534103601 cites W2073633602 @default.
• W2534103601 cites W2075604188 @default.
• W2534103601 cites W2091045467 @default.
• W2534103601 cites W2091408025 @default.
• W2534103601 cites W2105726520 @default.
• W2534103601 cites W2107116149 @default.
• W2534103601 cites W2108014789 @default.
• W2534103601 cites W2112936536 @default.
• W2534103601 cites W2117543913 @default.
• W2534103601 cites W2120070739 @default.
• W2534103601 cites W2122683221 @default.
• W2534103601 cites W2125222784 @default.
• W2534103601 cites W2126932378 @default.
• W2534103601 cites W2129078669 @default.
• W2534103601 cites W2129375421 @default.
• W2534103601 cites W2130410032 @default.
• W2534103601 cites W2137854396 @default.
• W2534103601 cites W2147017751 @default.
• W2534103601 cites W2150098952 @default.
• W2534103601 cites W2153268494 @default.
• W2534103601 cites W2160333540 @default.
• W2534103601 cites W2165108495 @default.
• W2534103601 cites W2168921000 @default.
• W2534103601 cites W2171874066 @default.
• W2534103601 cites W2256638742 @default.
• W2534103601 cites W2286975092 @default.
• W2534103601 cites W2342952088 @default.
• W2534103601 cites W2405393638 @default.
• W2534103601 cites W749462386 @default.
• W2534103601 cites W778834470 @default.
• W2534103601 doi "https://doi.org/10.1038/srep35421" @default.
• W2534103601 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5073332" @default.
• W2534103601 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27767123" @default.
• W2534103601 hasPublicationYear "2016" @default.
• W2534103601 type Work @default.
• W2534103601 sameAs 2534103601 @default.
• W2534103601 citedByCount "30" @default.
• W2534103601 countsByYear W25341036012017 @default.
• W2534103601 countsByYear W25341036012018 @default.
• W2534103601 countsByYear W25341036012019 @default.
• W2534103601 countsByYear W25341036012020 @default.
• W2534103601 countsByYear W25341036012021 @default.
• W2534103601 countsByYear W25341036012022 @default.
• W2534103601 countsByYear W25341036012023 @default.
• W2534103601 crossrefType "journal-article" @default.
• W2534103601 hasAuthorship W2534103601A5000613011 @default.
• W2534103601 hasAuthorship W2534103601A5018898066 @default.
• W2534103601 hasAuthorship W2534103601A5026672460 @default.
• W2534103601 hasAuthorship W2534103601A5038880076 @default.
• W2534103601 hasAuthorship W2534103601A5058502781 @default.
• W2534103601 hasAuthorship W2534103601A5079052592 @default.
• W2534103601 hasAuthorship W2534103601A5087404353 @default.
• W2534103601 hasAuthorship W2534103601A5091733618 @default.
• W2534103601 hasBestOaLocation W25341036011 @default.
• W2534103601 hasConcept C104317684 @default.
• W2534103601 hasConcept C126322002 @default.
• W2534103601 hasConcept C127561419 @default.
• W2534103601 hasConcept C134018914 @default.
• W2534103601 hasConcept C150194340 @default.
• W2534103601 hasConcept C186836561 @default.
• W2534103601 hasConcept C2776193436 @default.
• W2534103601 hasConcept C2777391703 @default.
• W2534103601 hasConcept C2780221984 @default.
• W2534103601 hasConcept C2992149932 @default.
• W2534103601 hasConcept C511355011 @default.
• W2534103601 hasConcept C54355233 @default.
• W2534103601 hasConcept C60644358 @default.
• W2534103601 hasConcept C62203573 @default.
• W2534103601 hasConcept C71924100 @default.

• next