Matches in SemOpenAlex for { <https://semopenalex.org/work/W2534202907> ?p ?o ?g. }
- W2534202907 abstract "Abstract Regenerating genes (Reg) have been found during the search for factors involved in pancreatic islet regeneration. Our recent study discovered that pancreatic β-cell-specific overexpression of Reg3β protects against streptozotocin (Stz) -induced diabetes in mice. To investigate its potential roles in the treatment of diabetes, we produced a recombinant Reg3β protein and provided evidence that it is active in promoting islet β-cell survival against Stz- triggered cell death. Though ineffective in alleviating preexisting diabetes, pretreatment of recombinant Reg3β was capable of minimizing the Stz-induced hyperglycemia and weight loss, by preserving serum and pancreatic insulin levels, and islet β-cell mass. No obvious changes were observed in the rate of cell proliferation and hypertrophy in α- or acinar-cells after treatment with recombinant Reg3β. The underlying mechanism of Reg3β-mediated protection seems to involve Akt activation which upregulates Bcl-2 and Bcl-xL levels and consequently promotes cell survival." @default.
- W2534202907 created "2016-10-28" @default.
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- W2534202907 date "2016-10-21" @default.
- W2534202907 modified "2023-10-16" @default.
- W2534202907 title "Recombinant Reg3β protein protects against streptozotocin-induced β-cell damage and diabetes" @default.
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- W2534202907 doi "https://doi.org/10.1038/srep35640" @default.
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