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- W2534237377 endingPage "641" @default.
- W2534237377 startingPage "632" @default.
- W2534237377 abstract "Systemic lupus erythematosus (SLE) is an autoimmune inflammatory disease with renal involvement in over half of the cases. In lupus nephritis (LN), podocytes are injured at the structural and molecular level. Spontaneous or induced animal models of SLE can reproduce the glomerular damage, similar to what is observed in humans. In this review, murine models focusing the podocyte injury were summarized, and therapeutic strategies to protect the podocyte cell were explored. Using the PubMed and MEDLINE databases from 1950 to 2015, literature search was conducted by article title and abstract, combining the following key words: “systemic lupus erythematosus,” “lupus nephritis,” “animal model,” “podocyte injury,” and “treatment.” Published or in-press eligible studies that were published as full-length articles in English-language journals were considered. Articles were summarized according to podocyte structure and function, the podocyte injury resulting from spontaneous (NZB/W F1 hybrid, MRL/lpr, and BXSB-Yaa mice) or induced (chronic graft-versus-host disease and pristane) mice models of LN, and the protective effects of drug treatments on podocyte cell structure and function reported in these models. Murine models of SLE have proven useful for better comprehension of the multiple mechanisms involved in systemic autoimmunity that leads to LN. These critical tools should be considered when target therapies are designed to control this disorder." @default.
- W2534237377 created "2016-10-28" @default.
- W2534237377 creator A5000514724 @default.
- W2534237377 creator A5014950444 @default.
- W2534237377 creator A5052386622 @default.
- W2534237377 creator A5068328001 @default.
- W2534237377 creator A5091559953 @default.
- W2534237377 date "2017-04-01" @default.
- W2534237377 modified "2023-10-05" @default.
- W2534237377 title "Unraveling the podocyte injury in lupus nephritis: Clinical and experimental approaches" @default.
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